Figure 1. XPA1 human pancreatic cancer cells are dimorphic. Stem-like XPA1 cells are spindle-shaped and spread throughout the surface of the culture flask (A), while non-stem XPA1 cells are round and tended to grow in a more clumped pattern (B). Dose response curves and the IC₅₀ for different chemotherapeutic drugs for each morphological type of XPA1 pancreatic carcinoma cells (C–F). Stem-like XPA1 cells were resistant to 5-FU and CDDP compared with non-stem XPA1 cells (C and D). In contrast, there was no difference between the efficacy of A1-R on stem-like and non-stem XPA1 cells (F). Scale bars, 20 μm. *P < 0.05.