Figure 4. In vitro ASM-024-induced relaxation of methacholine-contracted (A) dog and (B) human bronchi preparations and representative tension recording depicting relaxation response of dog bronchial rings and partial reversion after washing (C).
Values expressed as% of maximal methacholine-induced contraction are means ± SD; n = 8–18. * Significantly different from vehicle control, p<0.05; ** significantly different from vehicle control, p≤0.0001. Dog bronchi EC50 = 60.51±30.76 µM, human bronchi EC50 = 110.28±36.96 µM. Eq: equilibrium, MCh: methacholine.