Figure 2. T1R3 KO mice on a Western diet have fewer large adipocytes but increased adipocyte number.

A) The frequency distribution reveals that adipocyte sizes in epididymal adipose tissue from WT (n = 7) and T1R3 KO (n = 8) mice on a Western diet are shifted towards smaller cells. B) T1R3 KO animals have decreased frequency of large adipocytes, defined as having a surface area greater than 7500 µm², relative to WT animals. Significance was determined using Student’s t-test. P <0.05 indicated with #. Data are expressed as mean plus S.D. C) Linear relationship between eWAT (epididymal white adipose tissue) weight and average adipocyte volume for WT (r²  =  0.71) and T1R3 KO (r²  =  0.94) mice. Slope (P  =  0.14) and intercept (P < 0.05).