Figure 5. T1R2 KO mice have smaller adipocytes but equal adipocyte numbers.

A) Adipocyte size frequency distribution in WT (n = 9) and T1R2 KO (n = 9) mice on Western Diet for 14 weeks shows a greater prevalence of smaller adipocytes in T1R2 KO animals. B) T1R2 KO animals show a decreased frequency of large adipocytes, defined as having a surface area greater than 7000 µm², and increased frequency of small adipocytes, defined as having a surface area smaller than 7000 µm². Significance was determined using Student’s t-test. P <0.05 indicated with #. Data are expressed as mean plus S.D. C) Linear relationship between eWAT (epididymal white adipose tissue) weight and average adipocyte volume for WT (r² = 0.16) and T1R2 KO (r² = 0.60) mice. Slope (P = 0.98) and intercept (P = 0.43)