Figure 1. Expression of human TDP-43 in iTDP-43^14A and iTDP-43^8A mice in the postnatal period.

Immunohistochemical detection of hTDP-43 expression in cortex (CTX), hippocampus (HIP) and striatum (STR) in iTDP-43^14A (A) and iTDP-43^8A (B). Western analysis of organs demonstrated specificity of hTDP-43 expression to the brain in both iTDP-43^14A (C) and iTDP-43^8A (D) (SC = spinal cord, He = heart, Lu = lung, Li = liver, Ki = kidney, St = stomach, SM = skeletal muscle, Sp = spleen, Br = brain). (E) Brain weight measurement of non-transgenic (NT) and iTDP-43^14A mice at postnatal stages until 2 months of age (P60) (*p<0.05, **p<0.01, *** p<0.001, unpaired two tailed T-test). (F) Expression of hTDP-43 at indicated postnatal time points for iTDP-43^14A. (G) Expression of hTDP-43 at indicated postnatal time points for iTDP-43^14A (14) compared to iTDP-43^8A (8).