Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jan 22;9(1):e86496. doi: 10.1371/journal.pone.0086496

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 van Hartevelt et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A) Schematic overview of how the simulated FC matrices are obtained from the SC matrices using the dynamic mean field (DMF) model. The simulated FC matrices are subsequently compared to the empirical resting state FC matrix. B) Solid lines indicate the fitting of simulated functional connectivity (FC) matrices obtained with the pre-DBS (black), post-DBS (red), and healthy controls (blue) structural connectivity matrices with the empirical healthy FC, as a function of the global coupling weight (G). Vertical dashed lines indicate the corresponding bifurcation points, above which the dynamics becomes unstable. We observe that the bifurcation point of the post-DBS FC is shifted from the pre-DBS FC bifurcation point towards the healthy bifurcation point. This means that, before DBS, the structural connectivity is weaker and therefore stronger couplings are required to reach an optimal fitting with empirical FC The shift of the post-DBS bifurcation point towards the healthy bifurcation point indicates recovery of the structural connectivity with DBS.