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. 2014 Jan 22;9(1):e87279. doi: 10.1371/journal.pone.0087279

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© 2014 Takahashi et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A-C) The frequency of Sirius red-positive area is significantly higher in the MCD group than in the control group, and significantly lower in all the JHM groups than in the MCD group. The Sirius red-positive area is very small in the control group. (A: photomicrograph of a mouse of the MCD group, B: photomicrograph of a mouse of the TJ-48 group, ×400) (D–F) The rate of the SMA-positive area is significantly higher in the MCD group than in the control group, and significantly lower in the TJ-9, TJ-48, and TJ-25 groups than in the MCD group. (D: photomicrograph of a mouse of the MCD group, E: photomicrograph of a mouse of the TJ-9 group, ×400). ^aSignificantly different from the control group (P<0.05). ^bSignificantly different from the MCD group (P<0.05).