Table 2. Hazard ratios and 95% confidence intervals according to frequency of citrus fruit intake adjusted for potential confounders (men).

	Frequency of citrus fruit intake					P for trend
	Infrequent	1–2 times/month	1–2 times/week	3–4 times/week	Almost daily
Person-years	5785	11 847	15 333	7677	3511
Cardiovascular disease
No. of cases	47	60	98	44	21
HR1a (95% CIb)	1.00	0.67 (0.46–0.99)	0.73 (0.51–1.04)	0.57 (0.38–0.87)	0.58 (0.35–0.97)	0.02
HR2c (95% CI)	1.00	0.70 (0.47–1.05)	0.75 (0.52–1.09)	0.63 (0.41–0.97)	0.57 (0.33–1.01)	0.04
All-stroke
No. of cases	38	44	73	33	13
HR1 (95% CI)	1.00	0.60 (0.39–0.93)	0.66 (0.45–0.98)	0.52 (0.33–0.83)	0.43 (0.23–0.80)	0.01
HR2 (95% CI)	1.00	0.61 (0.39–0.96)	0.68 (0.45–1.03)	0.57 (0.35–0.92)	0.40 (0.20–0.81)	0.01
Cerebral infarction
No. of cases	27	32	56	24	7
HR1 (95% CI)	1.00	0.61 (0.37–1.02)	0.71 (0.45–1.12)	0.53 (0.31–0.92)	0.32 (0.14–0.75)	0.008
HR2 (95% CI)	1.00	0.65 (0.38–1.11)	0.73 (0.45–1.18)	0.62 (0.35–1.08)	0.28 (0.11–0.72)	0.02
Hemorrhagic stroke
No. of cases	11	12	17	9	6
HR1 (95% CI)	1.00	0.57 (0.25–1.29)	0.54 (0.25–1.15)	0.49 (0.20–1.19)	0.68 (0.25–1.83)	0.30
HR2 (95% CI)	1.00	0.52 (0.22–1.25)	0.57 (0.26–1.25)	0.45 (0.17–1.20)	0.71 (0.24–2.11)	0.36
Myocardial infarction
No. of cases	10	10	16	10	7
HR1 (95% CI)	1.00	0.57 (0.23–1.39)	0.62 (0.27–1.39)	0.68 (0.27–1.67)	1.01 (0.38–2.73)	0.91
HR2 (95% CI)	1.00	0.60 (0.25–1.49)	0.62 (0.27–1.43)	0.75 (0.30–1.86)	0.99 (0.34–2.80)	0.95

^aHazard ratio adjusted for age and study area.

^bConfidence interval.

^cHazard ratio adjusted for age, study area, body mass index, systolic blood pressure, total cholesterol concentration, physical activity index, smoking status, alcohol consumption, education level, and marital status.