Table 3. Hazard ratios and 95% confidence intervals according to frequency of citrus fruit intake adjusted for potential confounders (women).

	Frequency of citrus fruit intake					P for trend
	Infrequent	1–2 times/month	1–2 times/week	3–4 times/week	Almost daily
Person-years	5007	10 617	22 994	19 623	13 019
Cardiovascular disease
No. of cases	24	44	63	56	31
HR1a (95% CIb)	1.00	1.00 (0.61–1.64)	0.66 (0.41–1.06)	0.69 (0.43–1.11)	0.48 (0.28–0.83)	0.001
HR2c (95% CI)	1.00	0.83 (0.49–1.41)	0.68 (0.42–1.11)	0.75 (0.46–1.22)	0.51 (0.29–0.88)	0.02
All-stroke
No. of cases	20	37	53	47	25
HR1 (95% CI)	1.00	1.00 (0.58–1.72)	0.66 (0.39–1.10)	0.68 (0.40–1.14)	0.46 (0.25–0.83)	0.002
HR2 (95% CI)	1.00	0.84 (0.47–1.49)	0.67 (0.39–1.14)	0.73 (0.42–1.25)	0.47 (0.26–0.87)	0.02
Cerebral infarction
No. of cases	10	23	29	30	11
HR1 (95% CI)	1.00	1.29 (0.61–2.71)	0.77 (0.37–1.58)	0.94 (0.46–1.93)	0.43 (0.18–1.02)	0.02
HR2 (95% CI)	1.00	1.04 (0.47–2.33)	0.80 (0.37–1.73)	1.02 (0.48–2.20)	0.39 (0.15–1.00)	0.07
Hemorrhagic stroke
No. of cases	10	14	23	17	14
HR1 (95% CI)	1.00	0.72 (0.32–1.63)	0.54 (0.26–1.13)	0.45 (0.21–0.99)	0.49 (0.22–1.10)	0.05
HR2 (95% CI)	1.00	0.66 (0.29–1.52)	0.53 (0.25–1.13)	0.49 (0.22–1.08)	0.55 (0.24–1.23)	0.16
Myocardial infarction
No. of cases	2	3	10	5	3
HR1 (95% CI)	1.00	0.82 (0.14–4.93)	1.27 (0.28–5.84)	0.76 (0.15–4.00)	0.59 (0.10–3.54)	0.45
HR2 (95% CI)	1.00	0.83 (0.14–4.98)	1.47 (0.32–6.84)	0.84 (0.16–4.46)	0.67 (0.11–4.15)	0.57

^aHazard ratio adjusted for age and study area.

^bConfidence interval.

^cHazard ratio adjusted for age, study area, body mass index, systolic blood pressure, total cholesterol concentration, physical activity index, smoking status, alcohol consumption, education level, and marital status.