Table 4. Genotype distributions and allele frequencies of 108 selected genetic polymorphisms (107 SNPs and 1 insertion/deletion polymorphism).

Gene	Polymorphism	rs number	Genotypea			na				Frequency (proportion)						P for HWE	MAF
										Observed			Expectedb
			AA	Aa	aa	AA	Aa	aa	XX	AA	Aa	aa	AA	Aa	aa
ABCA1	C-565T	rs2422493	CC	CT	TT	1634	2137	746	2	0.362	0.473	0.165	0.358	0.481	0.161	0.29	0.402
ABCA1	G-191C	rs1800976	GG	GC	CC	1628	2144	746	1	0.360	0.475	0.165	0.357	0.481	0.162	0.37	0.402
ABCA1	G-17C	rs2740483	GG	GC	CC	2211	1898	409	1	0.489	0.420	0.091	0.489	0.420	0.090	0.94	0.301
ABCA1	Val825Ile (G/A)	rs2066715	GG	GA	AA	1877	2064	577	1	0.415	0.457	0.128	0.415	0.459	0.127	0.80	0.356
ABCA1	Val771Met (G/A)	rs2066718	GG	GA	AA	3945	550	23	1	0.873	0.122	0.005	0.872	0.123	0.004	0.40	0.066
ABCA1	Arg1587Lys (G/A)	rs2230808	GG	GA	AA	1673	2154	689	3	0.370	0.477	0.153	0.371	0.476	0.153	0.95	0.391
ABCC11	Arg180Gly (T/C)	rs17822931	TT	TC	CC	3368	1051	95	5	0.746	0.233	0.021	0.744	0.237	0.019	0.23	0.137
ACE	Insertion/Deletion (I/D)	rs1799752	I/I	I/D	D/D	1854	2021	634	10	0.411	0.448	0.141	0.404	0.463	0.133	0.029	0.365
ADD1	Trp460Gly (T/G)	rs4961	TT	TG	GG	1399	2163	956	1	0.310	0.479	0.212	0.301	0.495	0.203	0.026	0.451
ADH1B	His47Arg (A/G)	rs1229984	AA	AG	GG	2607	1659	250	3	0.577	0.367	0.055	0.579	0.364	0.057	0.54	0.239
ADH1C	Arg272Gln (C/T)	rs1693482	CC	CT	TT	3882	591	43	3	0.860	0.131	0.010	0.856	0.139	0.006	0.0005	0.075
ADIPOQ	C-11377G	rs266729	CC	CG	GG	2553	1663	301	2	0.565	0.368	0.067	0.561	0.376	0.063	0.18	0.251
ADIPOQ	Gly15Gly (T/G)	rs2241766	TT	TG	GG	2314	1789	415	1	0.512	0.396	0.092	0.504	0.412	0.084	0.011	0.290
ADIPOQ	G276T	rs1501299	GG	GT	TT	2498	1674	346	1	0.553	0.371	0.077	0.545	0.387	0.069	0.006	0.262
ADIPOQ	IVS-3971A/G	rs822396	AA	AG	GG	3984	517	16	2	0.882	0.114	0.004	0.882	0.114	0.004	1.00	0.061
ADIPOR1	G-8503A	rs6666089	GG	GA	AA	4234	272	7	6	0.938	0.060	0.002	0.938	0.061	0.001	0.22	0.032
ADIPOR1	C5843T	rs1342387	CC	CT	TT	1230	2206	1073	10	0.273	0.489	0.238	0.268	0.499	0.233	0.17	0.483
ADIPOR1	C10224G	rs7539542	CC	CG	GG	2788	1505	225	1	0.617	0.333	0.050	0.614	0.339	0.047	0.24	0.216
ADRB2	Gln27Glu (C/G)	rs1042714	CC	CG	GG	3943	551	20	5	0.874	0.122	0.004	0.873	0.122	0.004	0.81	0.065
ADRB3	Trp64Arg (T/C)	rs4994	TT	TC	CC	2932	1397	182	8	0.650	0.310	0.040	0.648	0.314	0.038	0.34	0.195
AGT	Thr174Met (C/T)	rs4762	CC	CT	TT	3615	848	52	4	0.801	0.188	0.012	0.800	0.189	0.011	0.75	0.105
AGT	Thr235Met (C/T)	rs699	CC	CT	TT	2989	1372	157	1	0.662	0.304	0.035	0.662	0.304	0.035	1.00	0.187
AGTR1(ATR1)	A1166C (at 3′UTR)	rs5186	AA	AC	CC	3777	695	45	2	0.836	0.154	0.010	0.834	0.159	0.008	0.048	0.087
ALDH2	Glu487Lys (G/A)	rs671	GG	GA	AA	2544	1649	321	5	0.564	0.365	0.071	0.557	0.379	0.064	0.018	0.254
APOA1	Ala61Thr (C/T)	rs12718465	CC	CT	TT	4036	463	18	2	0.894	0.103	0.004	0.893	0.104	0.003	0.25	0.055
APOA1	Arg184Pro (G/C)	rs5078	GG	GC	CC	4512	0	0	7	1.000	0.000	0.000	1.000	0.000	0.000	1.00	0.000
APOA5	T-1131C	rs662799	TT	TC	CC	1955	2001	556	7	0.433	0.443	0.123	0.429	0.452	0.119	0.21	0.345
APOA5	Gly185Cys (G553T)	rs2075291	GG	GT	TT	3920	559	32	8	0.869	0.124	0.007	0.867	0.129	0.005	0.020	0.069
APOE	T-203G	rs405509	TT	TG	GG	2213	1847	451	8	0.491	0.409	0.100	0.483	0.424	0.093	0.025	0.305
APOE	Arg158Cys (C/T) (at exon2)	rs7412	CC	CT	TT	4140	369	9	1	0.916	0.082	0.002	0.916	0.082	0.002	0.72	0.043
APOE	Cys112Arg (T/C) (at exon4)	rs429358	TT	TC	CC	3669	782	67	1	0.812	0.173	0.015	0.808	0.182	0.010	0.001	0.101
ARNTL(BMAL1)	A/G	rs7950226	AA	AG	GG	1638	2102	773	6	0.363	0.466	0.171	0.355	0.482	0.163	0.028	0.404
ART4(DOK1)	Leu208Leu (G/A)	rs3088189	GG	GA	AA	3595	875	47	2	0.796	0.194	0.010	0.797	0.192	0.012	0.48	0.107
ART4(DOK1)	Asp265Asn (G/A)	rs11276	GG	GA	AA	3597	872	48	2	0.796	0.193	0.011	0.797	0.191	0.011	0.59	0.107
BHMT	Arg239Gln (G742A)	rs3733890	GG	GA	AA	2765	1511	241	2	0.612	0.335	0.053	0.607	0.344	0.049	0.069	0.221
CBS	Tyr233Tyr (C699T)	rs234706	CC	CT	TT	4302	212	2	3	0.953	0.047	0.000	0.953	0.047	0.001	1.00	0.024
CD14	T-260C/T-159C	rs2569190	TT	TC	CC	1304	2256	958	1	0.289	0.499	0.212	0.290	0.497	0.213	0.79	0.462
CDKAL1	G/C	rs7754840	GG	GC	CC	1581	2195	740	3	0.350	0.486	0.164	0.352	0.483	0.166	0.64	0.407
CDKN2A/B	T/C	rs10811661	TT	TC	CC	1379	2205	934	1	0.305	0.488	0.207	0.302	0.495	0.203	0.34	0.451
CETP	A-629C	rs1800775	AA	AC	CC	1384	2242	891	2	0.306	0.496	0.197	0.308	0.494	0.198	0.76	0.445
CETP	Ile405Val (A/G)	rs5882	AA	AG	GG	1236	2116	1166	1	0.274	0.468	0.258	0.258	0.500	0.242	<0.0001	0.492
CETP	TaqIB (C/T)	rs708272	CC	CT	TT	1603	2174	741	1	0.355	0.481	0.164	0.354	0.482	0.164	0.93	0.405
CETP	G/T	rs3764261	GG	GT	TT	2707	1512	298	2	0.599	0.335	0.066	0.588	0.358	0.054	<0.0001	0.233
CHRNB2	G-42A	rs2072658	GG	GA	AA	2837	1518	161	3	0.628	0.336	0.036	0.634	0.324	0.042	0.015	0.204
CHRNB2	C/T (at 3′UTR)	rs2072660	CC	CT	TT	2601	1641	275	2	0.576	0.363	0.061	0.574	0.367	0.059	0.44	0.243
COMT	Val158Met (G/A)	rs4680	GG	GA	AA	2006	1983	528	2	0.444	0.439	0.117	0.440	0.446	0.113	0.27	0.336
CYP1A1	Ile462Val (A/G)	rs1048943	AA	AG	GG	2630	1620	268	1	0.582	0.359	0.059	0.580	0.363	0.057	0.39	0.239
CYP1A2	A734C	rs762551	AA	AC	CC	1878	2043	592	6	0.416	0.453	0.131	0.413	0.459	0.128	0.33	0.358
CYP11B2	T-344C	rs1799998	TT	TC	CC	2031	1976	507	5	0.450	0.438	0.112	0.447	0.443	0.110	0.42	0.331
CYP17A1	T-34C	rs743572	TT	TC	CC	1281	2257	977	4	0.284	0.500	0.216	0.285	0.498	0.217	0.79	0.466
ESR1	IVS1-351A/G (Xba I)	rs11155816	AA	AG	GG	4515	0	0	4	1.000	0.000	0.000	1.000	0.000	0.000	1.00	0.000
ESR1	IVS1-397T/C (Pvu II)	rs2234693	TT	TC	CC	1508	2172	834	5	0.334	0.481	0.185	0.330	0.489	0.181	0.30	0.425
ESR2	Val328Val (G1082A) (Rsa I)	rs1256049	GG	GA	AA	2320	1823	373	3	0.514	0.404	0.083	0.512	0.407	0.081	0.58	0.284
FTO	T/A	rs9939609	TT	TA	AA	2881	1454	183	1	0.638	0.322	0.041	0.638	0.322	0.041	1.00	0.201
GCK	G-30A	rs1799884	GG	GA	AA	2989	1348	181	1	0.662	0.298	0.040	0.657	0.307	0.036	0.065	0.189
GCKR	A/G	rs780094	AA	AG	GG	1379	2221	917	2	0.305	0.492	0.203	0.304	0.495	0.201	0.67	0.449
GCKR	Leu446Pro (T/C)	rs1260326	TT	TC	CC	1402	2214	902	1	0.310	0.490	0.200	0.308	0.494	0.198	0.61	0.445
GNAS1	T393C	rs7121	TT	TC	CC	1466	2233	817	3	0.325	0.494	0.181	0.327	0.490	0.183	0.52	0.428
IGF2BP2	G/T (at intron)	rs4402960	GG	GT	TT	2215	1866	436	2	0.490	0.413	0.097	0.486	0.422	0.092	0.14	0.303
IL-1B	T-31C	rs1143627	TT	TC	CC	1331	2196	990	2	0.295	0.486	0.219	0.289	0.497	0.214	0.14	0.462
IL-2	T-330G	rs2069762	TT	TG	GG	2033	1986	494	6	0.450	0.440	0.109	0.450	0.442	0.109	0.79	0.329
IL-4	T-33C	rs2070874	TT	TC	CC	1997	1989	531	2	0.442	0.440	0.118	0.439	0.447	0.114	0.30	0.338
IL-6	C-634G	rs1800796	CC	CG	GG	2611	1607	298	3	0.578	0.356	0.066	0.572	0.369	0.059	0.019	0.244
IL-8	T-251A	rs4073	TT	TA	AA	2077	1952	463	27	0.462	0.435	0.103	0.462	0.435	0.103	0.89	0.320
IL-10	T-819C	rs1800871	TT	TC	CC	1942	2009	557	11	0.431	0.446	0.124	0.427	0.453	0.120	0.29	0.346
IL-13	C-1111T	rs1800925	CC	CT	TT	3009	1359	147	4	0.666	0.301	0.033	0.667	0.299	0.034	0.69	0.183
KCNJ11	Glu23Lys (C/T)	rs5219	CC	CT	TT	1822	2081	615	1	0.403	0.461	0.136	0.401	0.464	0.134	0.59	0.366
LCAT/SLC12A4	Ser232Thr (T/A)	rs4986970	TT	TA	AA	4516	0	0	3	1.000	0.000	0.000	1.000	0.000	0.000	1.00	0.000
LIPC	T-514C	rs1800588	TT	TC	CC	1178	2255	1085	1	0.261	0.499	0.240	0.260	0.500	0.240	0.93	0.490
LIPC	Val95Met (G/A)	rs6078	GG	GA	AA	2659	1606	252	2	0.589	0.356	0.056	0.587	0.358	0.055	0.65	0.234
MPO	G-463A	rs2333227	GG	GA	AA	3612	852	52	3	0.800	0.189	0.012	0.800	0.189	0.011	0.81	0.106
MTHFD1	Arg134Lys (C401T)	rs1950902	CC	CT	TT	2773	1517	228	1	0.614	0.336	0.050	0.611	0.341	0.048	0.28	0.218
MTHFD1	Arg653Gln (G1958A)	rs2236225	GG	GA	AA	2340	1790	384	5	0.518	0.397	0.085	0.514	0.406	0.080	0.12	0.283
MTHFR	Ala222Val (C677T)	rs1801133	CC	CT	TT	1763	2060	694	2	0.390	0.456	0.154	0.382	0.472	0.146	0.023	0.382
MTHFR	Glu429Ala (A1298C)	rs1801131	AA	AC	CC	3023	1323	169	4	0.670	0.293	0.037	0.666	0.300	0.034	0.11	0.184
MTR	Asp919Gly (A/G)	rs1805087	AA	AG	GG	2883	1446	185	5	0.639	0.320	0.041	0.638	0.321	0.040	0.82	0.201
MTRR	Ile22Met (A66G)	rs1801394	AA	AG	GG	2155	1925	436	3	0.477	0.426	0.097	0.477	0.428	0.096	0.83	0.310
NOS3	T-786C	rs2070744	TT	TC	CC	3602	863	48	6	0.798	0.191	0.011	0.799	0.190	0.011	0.70	0.106
PPARD	T-842C (at exon3)	rs2267668	TT	TC	CC	2922	1421	172	4	0.647	0.315	0.038	0.647	0.315	0.038	1.00	0.195
PPARD	T-48444C (at exon3)	rs6902123	TT	TC	CC	4343	173	2	1	0.961	0.038	0.000	0.961	0.038	0.000	0.69	0.020
PPARD	Asn163Asn (A65G) (at exon7)	rs2076167	AA	AG	GG	2780	1530	204	5	0.616	0.339	0.045	0.617	0.337	0.046	0.76	0.215
PPARG	Pro12Ala (C/G)	rs1801282	CC	CG	GG	4236	274	5	4	0.938	0.061	0.001	0.938	0.061	0.001	0.80	0.031
PPARG	His477His (C161T)	rs3856806	CC	CT	TT	3231	1198	86	4	0.716	0.265	0.019	0.720	0.257	0.023	0.043	0.152
PPARGC1A	Thr394Thr (C/T)	rs2970847	CC	CT	TT	2755	1539	221	4	0.610	0.341	0.049	0.609	0.343	0.048	0.76	0.219
PPARGC1A	Gly482Ser (G/A)	rs8192678	GG	GA	AA	1317	2247	952	3	0.292	0.498	0.211	0.292	0.497	0.211	0.93	0.460
PRKAA2	IVS4+961T/C	rs1418442	TT	TC	CC	2677	1581	251	10	0.594	0.351	0.056	0.591	0.355	0.053	0.38	0.231
PRKAA2	IVS7+81T/C	rs932447	TT	TC	CC	2679	1585	252	3	0.593	0.351	0.056	0.591	0.356	0.053	0.38	0.231
PRKAA2	A/T (at 3′UTR)	rs1342382	AA	AT	TT	2739	1556	218	6	0.607	0.345	0.048	0.607	0.344	0.049	0.90	0.221
PTGS2(COX2)	G-765C	rs20417	GG	GC	CC	4260	247	6	6	0.944	0.055	0.001	0.943	0.056	0.001	0.27	0.029
PTGS2(COX2)	C-163G	rs5270	CC	CG	GG	4379	136	3	1	0.969	0.030	0.001	0.969	0.031	0.000	0.10	0.016
PTPN11	G33861A	rs2301756	GG	GA	AA	2926	1418	174	1	0.648	0.314	0.039	0.647	0.314	0.038	0.89	0.195
RETN	C-420G	rs1862513	CC	CG	GG	1956	1977	585	1	0.433	0.438	0.129	0.425	0.454	0.121	0.015	0.348
SCARB1	Val135Ile (G/A)	rs5891	GG	GA	AA	4518	0	0	1	1.000	0.000	0.000	1.000	0.000	0.000	1.00	0.000
SCARB1	Ala350Ala (C1119T)	rs5888	CC	CT	TT	2678	1619	221	1	0.593	0.358	0.049	0.596	0.352	0.052	0.25	0.228
SCARB1	G/A (at intron)	rs3782287	GG	GA	AA	2676	1574	268	1	0.592	0.348	0.059	0.588	0.358	0.055	0.074	0.234
SERPINC1	C/G	rs677	CC	CG	GG	2762	1527	227	3	0.612	0.338	0.050	0.609	0.342	0.048	0.41	0.219
SHMT1	Leu435Phe (C1420T)	rs1979277	CC	CT	TT	3755	722	41	1	0.831	0.160	0.009	0.830	0.162	0.008	0.36	0.089
SLC19A(RFC1)	His27Arg (A80G)	rs1051266	AA	AG	GG	1536	2187	793	3	0.340	0.484	0.176	0.339	0.486	0.175	0.76	0.418
SLC30A8	Arg325Trp (C/T)	rs13266634	CC	CT	TT	1543	1992	976	8	0.342	0.442	0.216	0.317	0.492	0.191	<0.0001	0.437
SRD5A2	Leu89Val (C/G)	rs523349	CC	CG	GG	1334	2286	896	3	0.295	0.506	0.198	0.301	0.495	0.204	0.15	0.452
TAS2R38	Pro49Ala (C/G)	rs713598	CC	CG	GG	1399	2219	898	3	0.310	0.491	0.199	0.309	0.494	0.198	0.74	0.445
TAS2R38	Ala262Val (C/T)	rs1726866	CC	CT	TT	1401	2218	899	1	0.310	0.491	0.199	0.309	0.494	0.198	0.70	0.444
TAS2R38	Val296Ile (C/T)	rs10246939	CC	CT	TT	1401	2218	898	2	0.310	0.491	0.199	0.309	0.494	0.197	0.72	0.444
TCF7L2	C/T (at intron)	rs7903146	CC	CT	TT	4174	333	11	1	0.924	0.074	0.002	0.923	0.075	0.002	0.11	0.039
TNF-A	T-1031C	rs1799964	TT	TC	CC	3147	1244	127	1	0.697	0.275	0.028	0.696	0.277	0.027	0.75	0.166
TNF-A	C-857T	rs1799724	CC	CT	TT	2990	1365	162	2	0.662	0.302	0.036	0.661	0.304	0.035	0.70	0.187
USF1	C7131T	rs3737787	CC	CT	TT	2793	1506	218	2	0.618	0.333	0.048	0.616	0.338	0.046	0.43	0.215
VDR	Met1Thr (Fok I) (C/T)	rs2228570	CC	CT	TT	1768	2105	643	3	0.391	0.466	0.142	0.390	0.469	0.141	0.68	0.375

Abbreviations: HWE, Hardy–Weinberg equilibrium; MAF, minor allele frequency; SNP, single nucleotide polymorphism.

^aAA, Aa, aa, and XX indicate homozygotes of major alleles, heterozygotes, homozygotes of minor alleles, and samples for which the genotype could not be determined, respectively.

^bBased on the Hardy–Weinberg equilibrium.