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The non-genomic effects of ER-α36. ER-α36 activated by E2 interacts with adaptor proteins (adaptor) and downstream signaling molecules such as c-Src, which mediates rapid signaling via PI3K/Akt and MAPK/ERK pathways. ER-α36 also turns on other downstream kinases like c-Jun N-terminal kinases (JNK) and intracellular Ca2+ mobilization. The interactions between ER-α36 and EGFR/GPER are also involved in the non-genomic signaling.
