. 2014 Jan 21;12:16. doi: 10.1186/1479-5876-12-16

Table 1.

Expression of ER-α36 in cancers

*Tumor type ()**	Study	Kind/num. of analyzed samples	Method ()**	Potential clinical significant
BC	Lee, et al.[16]	37 BC tissues	IHC/WB	Inverse association with ER-α66 expression
BC	Shi, et al.[38]	896 BC tissues	IHC	ER-α66+/ER-α36Hi tumors are less likely to benefit from tamoxifen treatment than ER-α66+/ER-α36- tumors
BC	Zheng, et al.[59]	74 pairs of BC tissues and matched normal tissues	PCR	Lower expression in BC tissues than in matched normal tissues.
BC	Zheng, et al.[59]	74 pairs of BC tissues and matched normal tissues	PCR	Inverse association with local progression/lymph node metastasis/advanced cancer stage.
BC	Zhang, et al.[34]	12 triple-negative BC tissues	IHC	Expressed in triple-negative BC
BC	Pelekanou, et al.[58]	49 triple-negative BC tissues % 34 matched normal samples	IHC	Highly expressed in triple negative BC.
BC	Pelekanou, et al.[58]	49 triple-negative BC tissues % 34 matched normal samples	IHC	Positive association with overall survival rate
BC	Vranic, et al.[33]	19 pure apocrine carcinomas and 11 adenoid cystic carcinomas of the breast	IHC	Highly expressed in ER-α66 negative apocrine and adenoid cystic carcinomas of the breast.
BC	Vranic, et al.[33]		IHC	Higher expression in the malignant epithelium than adjacent normal breast tissue
BC	Zhang, et al.[35]	20 BC tissues	IHC	Inverse association with ER-α66 expression
EC	Tu, et al.[17]	45 EC tissues	IHC	Positive association with high-stage/high-grade
EC	Sun, et al. [60]	73 EC tissues, 20 normal endometrial tissues % 9 atypical endometrial hyperplasia	IHC	Lower expression in EC tissues than in normal endometrial tissues and atypical hyperplasia.
EC	Sun, et al. [60]		IHC	Inverse association with disease-free survival rate
HCC	Miceli, et al.[20]	5 normal liver tissues,8 liver cirrhosis specimens % 8 HCC tissues	PCR	Inverse association with ER-α66 expression.
HCC	Miceli, et al.[20]		PCR	Increase in a stepwise manner from non-tumoural tissues, cirrhotic tissues to HCC tissues.
CRC	Jiang, et al.[18]	35 CRC tissues and their matched normal tissues	PCR	Lower expression in CRC than matched normal tissues.
CRC	Jiang, et al.[18]	35 CRC tissues and their matched normal tissues	PCR	Inverse association with tumour stage/lymph node metastasis.
GC	Deng, et al.[61]	22 GC tissues	IHC	Higher expression in GC than paired normal tissues.
GC	Deng, et al.[61]	22 GC tissues	IHC	Positive association with lymph node metastasis
GC	Wang, et al.[19]	45 GC tissues and matched normal tissues	PCR	Lower expression in GC than normal tissues

(*) Tumor type: BC: Breast Cancer, EC: Endometrial Cancer, HCC: Hepatocellular Carcinoma, CRC: Colorectal Cancer, GC: Gastric Cancer.

(**) Method: WB: Western blotting, IHC: Immunohistochemistry, PCR: Polymerase chain reaction.