Table 1.
Tumor type (*) | Study | Kind/num. of analyzed samples | Method (**) | Potential clinical significant |
---|---|---|---|---|
BC |
Lee, et al.[16] |
37 BC tissues |
IHC/WB |
Inverse association with ER-α66 expression |
BC |
Shi, et al.[38] |
896 BC tissues |
IHC |
ER-α66+/ER-α36Hi tumors are less likely to benefit from tamoxifen treatment than ER-α66+/ER-α36- tumors |
BC |
Zheng, et al.[59] |
74 pairs of BC tissues and matched normal tissues |
PCR |
Lower expression in BC tissues than in matched normal tissues. |
Inverse association with local progression/lymph node metastasis/advanced cancer stage. | ||||
BC |
Zhang, et al.[34] |
12 triple-negative BC tissues |
IHC |
Expressed in triple-negative BC |
BC |
Pelekanou, et al.[58] |
49 triple-negative BC tissues % 34 matched normal samples |
IHC |
Highly expressed in triple negative BC. |
Positive association with overall survival rate | ||||
BC |
Vranic, et al.[33] |
19 pure apocrine carcinomas and 11 adenoid cystic carcinomas of the breast |
IHC |
Highly expressed in ER-α66 negative apocrine and adenoid cystic carcinomas of the breast. |
Higher expression in the malignant epithelium than adjacent normal breast tissue | ||||
BC |
Zhang, et al.[35] |
20 BC tissues |
IHC |
Inverse association with ER-α66 expression |
EC |
Tu, et al.[17] |
45 EC tissues |
IHC |
Positive association with high-stage/high-grade |
EC |
Sun, et al. [60] |
73 EC tissues, 20 normal endometrial tissues % 9 atypical endometrial hyperplasia |
IHC |
Lower expression in EC tissues than in normal endometrial tissues and atypical hyperplasia. |
Inverse association with disease-free survival rate | ||||
HCC |
Miceli, et al.[20] |
5 normal liver tissues,8 liver cirrhosis specimens % 8 HCC tissues |
PCR |
Inverse association with ER-α66 expression. |
Increase in a stepwise manner from non-tumoural tissues, cirrhotic tissues to HCC tissues. | ||||
CRC |
Jiang, et al.[18] |
35 CRC tissues and their matched normal tissues |
PCR |
Lower expression in CRC than matched normal tissues. |
Inverse association with tumour stage/lymph node metastasis. | ||||
GC |
Deng, et al.[61] |
22 GC tissues |
IHC |
Higher expression in GC than paired normal tissues. |
Positive association with lymph node metastasis | ||||
GC | Wang, et al.[19] | 45 GC tissues and matched normal tissues | PCR | Lower expression in GC than normal tissues |
(*) Tumor type: BC: Breast Cancer, EC: Endometrial Cancer, HCC: Hepatocellular Carcinoma, CRC: Colorectal Cancer, GC: Gastric Cancer.
(**) Method: WB: Western blotting, IHC: Immunohistochemistry, PCR: Polymerase chain reaction.