Table 3.
Statistical comparison [point estimates (90 % CIs)]
| Comparison | Compound | Normalization | AUClast | C max |
|---|---|---|---|---|
| Japanese vs. Caucasian | Unconjugated rotigotine | None | 1.10 (0.84–1.44) | 1.14 (0.88–1.47) |
| Body weight | 1.01 (0.77–1.32) | 1.04 (0.8–1.35) | ||
| Apparent dose | 1.15 (0.93–1.42) | 1.18 (0.96–1.45) | ||
| Body weight + apparent dose | 1.05 (0.85–1.28) | 1.08 (0.88–1.32) | ||
| Total rotigotine | None | 1.32 (1.08–1.62) | 1.37 (1.12–1.68) | |
| Body weight | 1.21 (0.98–1.49) | 1.25 (1.01–1.56) | ||
| Apparent dose | 1.37 (1.18–1.59) | 1.42 (1.23–1.65) | ||
| Body weight + apparent dose | 1.25 (1.08–1.45) | 1.30 (1.12–1.52) | ||
| Male vs. female | Unconjugated rotigotine | None | 0.69 (0.53–0.90) | 0.66 (0.51–0.85) |
| Body weight | 0.81 (0.62–1.06) | 0.78 (0.60–1.01) | ||
| Apparent dose | 0.78 (0.63, 0.96) | 0.74 (0.60, 0.91) | ||
| Body weight + apparent dose | 0.91 (0.75–1.12) | 0.88 (0.72–1.07) | ||
| Total rotigotine | None | 0.88 (0.72–1.08) | 0.89 (0.73–1.10) | |
| Body weight | 1.04 (0.84–1.29) | 1.05 (0.85–1.31) | ||
| Apparent dose | 1.00 (0.86–1.16) | 1.01 (0.87–1.17) | ||
| Body weight + apparent dose | 1.18 (1.01–1.37) | 1.19 (1.02–1.38) |
AUC last area under the plasma concentration–time curve from time zero to last quantifiable concentration, C max maximum plasma concentration