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. 2013 Nov 9;34(2):107–115. doi: 10.1007/s40261-013-0151-4

Table 2.

Demographic and baseline characteristics and concomitant medications by treatment group

Characteristic Paricalcitol Cinacalcet p valuea
Subjects [n] 51 47
Age [years; mean ± SD] 61.0 ± 11.5 60.7 ± 11.6 0.8984
Male [n (%)] 31 (60.8) 28 (59.6) 0.9027
Race [n (%)] 0.3147
 White 24 (47.1) 26 (55.3)
 Black 25 (49.0) 19 (40.4)
 Other 2 (4.0) 2 (4.3)
Hispanic [n (%)] 11 (21.6) 13 (27.7) 0.4836
Diabetes [n (%)]
 Type 1 5 (9.8) 1 (2.1) 0.1133
 Type 2 33 (64.7) 26 (55.3) 0.3429
Cardiovascular disease [n (%)]
 Angina 7 (13.7) 1 (2.1) 0.0362
 Myocardial infarction 10 (19.6) 4 (8.5) 0.1168
 Coronary artery disease 20 (39.2) 13 (27.7) 0.2265
 Left ventricular hypertrophy 11 (21.6) 2 (4.3) 0.0116
Duration of dialysis [years; mean ± SD] 3.9 ± 3.3 3.9 ± 3.3 0.9948
Blood pressure [mmHg; mean ± SD]
 Systolic 142.8 ± 26.1 149.4 ± 24.7 0.2016
 Diastolic 72.7 ± 12.9 76.5 ± 15.2 0.1839
Concomitant medications [n (%)]
 Angiotensin-converting enzyme inhibitors 20 (39.2) 18 (38.3) 0.9258
 Angiotensin II receptor blockers 9 (17.6) 7 (14.9) 0.7126
 Beta blockers 35 (68.6) 27 (57.4) 0.2514
 Calcium channel blockers 26 (51.0) 24 (51.1) 0.9934
 Diuretics 16 (31.4) 9 (19.1) 0.1655
 Erythropoiesis-stimulating agents 43 (84.3) 38 (80.8) 0.6511
Baseline laboratory values
 Serum iPTH level [pg/mL; mean ± SD] 516.6 ± 147.9 524.3 ± 149.7 0.7984
 Corrected calcium level [mg/dL; mean ± SD] 9.0 ± 0.5 9.1 ± 0.4 0.5402
 Phosphorus level [mg/dL; mean ± SD] 4.8 ± 1.0 5.0 ± 1.0 0.4789
 Alkaline phosphatase level [IU/L; mean ± SD] 111.9 ± 52.8 126.9 ± 52.4 0.1617
 Bone-specific alkaline phosphatase level [U/L; mean ± SD] 35.7 ± 15.8 41.7 ± 26.7 0.1801
 25-hydroxy vitamin D level [ng/mL; mean ± SD]b 23.0 ± 14.0 23.7 ± 9.7 0.8148
 Creatinine level [mg/dL; mean ± SD]c 8.1 ± 2.3 9.0 ± 2.5 0.0994
 Albumin level [g/dL; mean ± SD] 4.0 ± 0.2 4.0 ± 0.3 0.6989

iPTH intact parathyroid hormone, SD standard deviation

aDifferences between groups were considered statistically significant (indicated by bold text) if p < 0.05 on the basis of Pearson’s chi-squared test or Student’s t test

bNot all subjects had a baseline value recorded for this item—n = 36 in the paricalcitol group and n = 36 in the cinacalcet group

cNot all subjects had a baseline value recorded for this item—n = 46 in the paricalcitol group and n = 50 in the cinacalcet group