Fig. 1.

Effect of odanacatib (ODN) and alendronate (ALN) treatment on bone resorption parameters in ovariectomized (OVX) rabbits. The extent of eroded surface (ES/BS) and osteoclast surface (Oc.S/BS) was assessed in the vertebral trabecular bone of sham and OVX rabbits treated with vehicle (Veh), ALN, or ODN. The results are shown as means with SD a or as medians with upper and lower quartiles b. Differences between the groups were analyzed by the Mann–Whitney test b or the t-test a, applying Welch correction in the presence of unequal group variances. *p < 0.05, **p < 0.01, ***p < 0.001