Fig. 3.

Effects of odanacatib (ODN) and alendronate (ALN) treatment on osteoclast features. a The extent of osteoclast profiles detached from the bone surface was evaluated in the vertebral trabecular bone of sham and ovariectomized (OVX) rabbits treated with vehicle (Veh), ALN, or ODN. Data are expressed as the percentage of detached osteoclast profiles per total number of osteoclast profiles. b Among the osteoclast profiles detached from the bone surface, some covered tightly reversal cells (Rv.Cs). The fraction of this population of osteoclasts is expressed as percentage of the total detached osteoclasts. c Percentage of osteoclast profiles attached onto bone surfaces with an erosion depth of ≤2 lamellae. d Percentage of osteoclast profiles with demineralized collagen below. e Percentage of osteoclast profiles with intracellular vesicles. Results are shown as medians with upper and lower quartiles a or as means with SD b–e. Rabbits with fewer than 20 osteoclast profiles were excluded from the analyses. Differences between groups were analyzed by the Mann–Whitney test a or the t-test b–e, applying the Welch correction in the presence of unequal group variances. *p < 0.05, **p < 0.01, ***p < 0.001