Fig. 5.

Effect of odanacatib (ODN) and alendronate (ALN) treatment on bone formation parameters. The extent of osteoid surface (OS/BS) a, total osteoblast surface (Ob.S/BS) b, and cuboidal osteoblast surface (C.Ob.S/BS) c was evaluated in a vertebra from the sham and OVX rabbits treated with vehicle (Veh), ALN, or ODN. d The density of osteoblasts (cell profiles per millimeter) is shown for each of the four groups. Results are shown as medians with upper and lower quartiles a–c or means with SD d. The Mann–Whitney a–c or the t-test d was used to analyze whether the parameters were significantly different in the four groups. *p < 0.05, **p < 0.01