Table 1.
Effects of OVX, ALN and ODN on structural indices of trabecular bone
| Group | n | BV/TV (%) | Tb.Th (μm) | Tb.N (#/mm) | Tb.Sp (μm) |
|---|---|---|---|---|---|
| Sham | 11 | 15 ± 3 | 102 ± 14 | 1.7 (1.3, 2.2) | 456 (342, 628) |
| OVX + veh | 12 | 11 ± 2** | 101 ± 14 | 1.2 (1, 1.5)* | 726 (576, 912)* |
| OVX + ALN | 11 | 15 ± 5†† | 124 ± 26* † | 1.3 (1.1, 1.6)* | 688 (511, 783)* |
| OVX + ODN | 12 | 12 ± 3 | 121 ± 16** †† | 1.2 (0.9, 1.5) | 735 (554, 1049) |
BV/TV and Tb.Th are expressed as mean values ± SD and Tb.N and Tb.Sp as median values, where the first number in parentheses is the first quartile and the second number is the third quartile
* p < 0.05 against sham, ** p < 0.01 against sham, † p < 0.05 against OVX + veh, †† p < 0.01 against OVX + veh
OVX ovariectomy, ALN alendronate, ODN odanacatib, BV/TV bone volume/total volume, Tb.Th trabecular thickness, Tb.N trabecular number, Tb.Sp trabecular spacing