Table 3.

Formulations of botulinum toxin

Trade name	Company	Nonproprietary name	Type	SNARE target	Preparation	Storage temperature	Units per vial	US FDA approved indications for dystonia (year approved)
Botox	Allergan, Irvine, CA, USA	OnabotulinumtoxinA	A	SNAP25	Powder	<8 °C	50, 100, 200	Blepharospasm (1989); cervical dystonia (2000)
Dysport	Ipsen, Slough, UK	AbobotulinumtoxinA	A	SNAP25	Powder	<8 °C	300, 500	Cervical dystonia (2009)
Xeomin	Merz Pharmaceuticals, Greensboro, NC, USA	IncobotulinumtoxinA	A	SNAP25	Powder	<25 °C	50, 100	Blepharospasm; cervical dystonia (2010)
Myobloc	US World Meds, Louisville, KY, USA	RimabotulinumtoxinB	B	VAMP	Solution	<8 °C	2500, 5000, 10,000	Cervical dystonia (2000)

SNARE = soluble N-ethylmaleimide-sensitive factor attachment receptor proteins; SNAP = soluble N-ethylmaleimide sensitive fusion protein (NSF) attachment protein; VAMP = vesicle-associated membrane protein; FDA = Federal Drug Administration