Table 1.
Receptor | Location | Stage of disease |
---|---|---|
Adenosine A2A | Striatum, GPe | Preclinical to advanced |
Cannabinoid | Striatum, GPe | Preclinical to advanced |
Dopamine D1 | Striatum, substantia nigra | Clinical diagnosis to advanced |
Dopamine D2 | Caudate, putamen | Prodromal |
Dynorphin | Striatum | Emergence of dystonia |
Enkephalin | Striatum | Emergence of chorea |
GABA | Striatum | Advanced |
Glutamate | Cortical | Preclinical to advanced |
Substance P | Striatum | Emergence of dystonia |
GPe = globus pallidus externa; GABA = γ-aminobutyric acid.