Table 2.

Association of polymorphic variants of CTNNB1, APC, and AXIN2 with the risk of ovarian cancer

Gene	rs no.	Allelesa	MAFb	Genotypes casesc	Genotypes controlsc	p genotypic value	p trend value	p allelic value	ORdominant (95 % CI)d; p value	ORrecessive (95 % CI)e; p value
CTNNB1	rs4533622	a/C	0.46	78/113/37	90/122/70	0.057	0.092	0.082	0.901 (0.622–1.306); 0.583	0.587 (0.376–0.915); 0.018
CTNNB1	rs2953	g/T	0.46	78/113/37	90/122/70	0.057	0.092	0.082	0.901 (0.622–1.306); 0.583	0.587 (0.376–0.915); 0.018
APC	rs11954856	g/T	0.48	35/129/63	76/141/64	0.007	0.007	0.009	2.034 (1.302–3.178); 0.002	1.302 (0.871–1.948); 0.198
APC	rs351771	c/T	0.45	88/114/26	86/139/57	0.015	0.006	0.006	0.698 (0.483–1.009); 0.055	0.508 (0.308–0.839); 0.007
APC	rs459552	a/T	0.30	129/86/13	142/108/32	0.064	0.041	0.034	0.778 (0.548–1.106); 0.161	0.472 (0.242–0.923); 0.025
AXIN2	rs4074947	C/t	0.19	137/80/10	182/89/10	0.577	0.298	0.302	1.208 (0.841–1.734); 0.306	1.249 (0.510–3.056); 0.626
AXIN2	rs7224837	A/g	0.15	161/61/6	203/71/8	0.917	0.801	0.799	1.069 (0.727–1.573); 0.733	0.926 (0.316–2.708); 0.888
AXIN2	rs3923087	a/G	0.22	133/84/10	171/97/14	0.814	0.775	0.777	1.089 (0.763–1.555); 0.640	0.882 (0.384–2.026); 0.767
AXIN2	rs2240308	A/g	0.49	67/115/46	71/146/65	0.510	0.254	0.260	0.809 (0.546–1.197); 0.288	0.844 (0.551–1.292); 0.434

Statistically significant results are highlighted in bold

Experiment-wide significance threshold required to keep Type I error rate at 5 % (Nyholt correction): 0.006 (effective number of independent marker loci: 8.388)

MAF minor allele frequency, OR odds ratio, p _trend p values of the trend test

^aUppercase denotes the more frequent allele in the control samples

^bCalculated from the control samples

^cThe order of genotypes: DD/Dd/dd (d is the minor allele in the control samples)

^dDominant model: dd + Dd vs. DD (d is the minor allele)

^eRecessive model: dd vs. Dd + DD (d is the minor allele)