Table 3. Multivariable-adjusted associations between body mass index and mammographic density after additional adjustment for lipid parameters.
| Additionally adjusted lipid parameter (mmol/L)d |
Dense area (cm2) | Percent dense area, % | ||||
| Premenopausal women (n = 456) |
Postmenopausal women (n = 255) |
All women (n = 711) |
Premenopausal women (n = 456) |
Postmenopausal women (n = 255) |
All women (n = 711) |
|
| β (95% CI)a | β (95% CI)b | β (95% CI)c | β (95% CI)a | β (95% CI)b | β (95% CI)c | |
| None | −0.02 (−0.04, 0.002) | −0.05 (−0.11, 0.008) | −0.02 (−0.04, −0.002) | −0.08 (−0.09, −0.06) | −0.11 (−0.17, −0.05) | −0.08 (−0.10, −0.06) |
| Total cholesterol | −0.02 (−0.04, 0.002) | −0.05 (−0.11, 0.02) | −0.02 (−0.04, −0.003) | −0.07 (−0.09, −0.06) | −0.11 (−0.17, −0.04) | −0.08 (−0.10, −0.06) |
| HDL cholesterol | −0.02 (−0.04, 0.004) | −0.04 (−0.11, 0.03) | −0.02 (−0.04, −0.002) | −0.07 (−0.09, −0.05) | −0.10 (−0.17, −0.02) | −0.08 (−0.10, −0.06) |
| LDL cholesterol | −0.02 (−0.04, 0.002) | −0.05 (−0.12, 0.02) | −0.02 (−0.04, −0.003) | −0.07 (−0.09, −0.05) | −0.11 (−0.17, −0.04) | −0.08 (−0.10, −0.06) |
| Triglyceride | −0.01 (−0.04, 0.007) | −0.05 (−0.12, 0.02) | −0.02 (−0.04, −0.001) | −0.07 (−0.09, −0.05) | −0.11 (−0.18, −0.04) | −0.08 (−0.10, −0.06) |
HDL, high-density lipoprotein; LDL, low-density lipoprotein.
aβ (95% confidence interval) was estimated by using a linear mixed model in which random effects (household, twin pair) and fixed effects (age, smoking status, alcohol consumption, physical exercise, education level, number of live children, age at first childbirth, duration of breast feeding, and oral contraceptive pill use) were adjusted for.
bModel additionally adjusted for use of hormone replacement therapy as a fixed effect.
cModel additionally adjusted for menopausal status and use of hormone replacement therapy as fixed effects.
dModel additionally adjusted for each lipid parameter as a fixed effect.