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. Author manuscript; available in PMC: 2014 Jan 23.
Published in final edited form as: Free Radic Res. 2010 Oct 13;45(2):156–164. doi: 10.3109/10715762.2010.520319

Figure 2.

Figure 2

(A) Representative liver sections of untreated control mice or animals treated for 6 h with 200 mg/kg acetaminophen (APAP) and stained with H&E. (B) DNA fragmentation as evaluated by the TUNEL assay in mice treated with APAP for 6 h. (C) Nitrotyrosine staining as an indicator of peroxynitrite formation in mice treated with APAP for 6 h. Inserted images of serial liver sections from wild type animals treated with APAP indicate that the centrilubular location of cell necrosis correlates with the area of TUNEL and nitrotyrosine staining.