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Effects of cocaine on locomotor activity in naive M4−/− mice (white) and M4+/+ mice (black). M4−/− mice and control littermates (n=5-10) were injected subcutaneously with the indicated doses of cocaine. Locomotor activity was assessed during a 1 h test period. *p<0.05 vs. control; post-hoc t-test following overall significant genotype effect in two-way ANOVA.
