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. 2014 Jan 23;4:394. doi: 10.3389/fphys.2013.00394

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Copyright © 2014 Nielsen, Hvid, Kelly, Lindegaard, Dethlefsen, Winding, Mathur, Scheele, Pedersen and Laye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MyomiR expression in human skeletal muscle from elderly and younger individuals. Muscle biopsies were obtained from a cohort of healthy elderly and younger men and women (n = 9 in each group) and myomiR levels were measured by using qPCR. An ordinary Two-Way ANOVA revealed an overall effect of both gender and age on miR-133a and miR-133b expression (B,C) (^**P < 0.01) and a significant interaction for miR-1 expression (^**P < 0.01). When using Bonferroni multiple comparison post-hoc test it was demonstrated that miR-1 (A), miR-133a (B), and miR-133b (C) expression levels were higher in elderly compared to younger men (^*P = 0.02, ^*P = 0.03, ^***P = 0.008, respectively) There was no effect of age or gender on mir-206 expression (D) (P > 0.05). Data are mean ± SEM.