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. 2014 Jan 23;4:394. doi: 10.3389/fphys.2013.00394

Figure 3.

Figure 3

MyomiR expression in testosterone depleted men before and after training. MyomiR expression in the skeletal muscle of LHRH agonist treated prostate cancer patients (n = 8) and healthy controls (n = 8), in resting samples prior to and following 12 weeks of aerobic exercise training. A Two-Way ANOVA (RM) (miR-1, ****P < 0.0001. miR-133a, **P < 0.01. miR-133b, ***P < 0.001, miR-206 *P < 0.05). Bonferroni multiple comparison post-hoc tests revealed a significant lower expression of mir-133a (B) (*P = 0.02) and mir-133b (C) (*P = 0.03), but not mir-1 (A) or miR-206 (D) in testosterone blocked patients at rest before training. The expression of myomiRs in testosterone blocked patients and healthy controls were identical after the training period. The expression of MYOG (E) (*P < 0.05) at rest was upregulated in testosterone-blocked participants. No regulation of MYOD, MYF-5, or AR was detected. Data are mean ± SEM.