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. 2014 Jan 23;4:394. doi: 10.3389/fphys.2013.00394

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Copyright © 2014 Nielsen, Hvid, Kelly, Lindegaard, Dethlefsen, Winding, Mathur, Scheele, Pedersen and Laye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Muscle of castrated (n = 5) and sham operated (n = 4) C57BL/6J mice. An unpaired t-test demonstrated a significant lower expression of mir-133a (^*P < 0.05) and mir-133b (^***P < 0.001) in the skeletal muscle of castrated mice. The expression of mir-1 and mir-206 were not significantly different between castrated and sham operated mice (A). Whereas the expression of Myog was upregulated (^*P< 0.05) in castrated mice, no regulation of Myod, Myf-5, or Ar was detected (P > 0.05) (B). Data are mean ± SEM.