Table 3.
Genes which show a significant interaction between maternal nutritional status and postnatal leptin treatment effects, an expression change of at least 1.25 fold in the UN/Sal/HF cohort (with metabolic syndrome), and where this cohort is an outlier from the other experimental groups
| Symbol | Fold change in USC | Fold change in USH | Significant factors | Entrez ID | Definition |
|---|---|---|---|---|---|
|
Ifit1 |
2.95 |
3.52 |
AB |
56824 |
Rattus norvegicus interferon-induced protein with tetratricopeptide repeats 1 (Ifit1), mRNA. |
|
Ppp1r3b |
1.46 |
2.40 |
AB, C |
192280 |
Rattus norvegicus protein phosphatase 1, regulatory (inhibitor) subunit 3B (Ppp1r3b), mRNA. |
|
Ca3 |
1.29 |
2.38 |
AB, C |
54232 |
Rattus norvegicus carbonic anhydrase 3 (Ca3), mRNA. |
|
Stac3 |
1.27 |
2.35 |
AB, C |
362895 |
PREDICTED: Rattus norvegicus SH3 and cysteine rich domain 3 (predicted) (Stac3_predicted), mRNA. |
|
TUBB2A |
1.79 |
2.33 |
AB, BC |
498736 |
PREDICTED: Rattus norvegicus similar to tubulin, beta 2 (TUBB2A), mRNA. |
|
LEAP2 |
1.52 |
2.29 |
AB, C |
497901 |
PREDICTED: Rattus norvegicus similar to Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) (LEAP2), mRNA. |
|
Slc34a2 |
1.45 |
1.88 |
AB, C |
84395 |
Rattus norvegicus solute carrier family 34 (sodium phosphate), member 2 (Slc34a2), mRNA. |
| Pgd |
1.24 |
1.77 |
AB |
362660 |
PREDICTED: Rattus norvegicus phosphogluconate dehydrogenase (Pgd), mRNA. |
|
Afp |
1.33 |
1.76 |
AB, C |
24177 |
Rattus norvegicus alpha-fetoprotein (Afp), mRNA. |
| VNN3 |
1.17 |
1.70 |
AB, C |
498992 |
PREDICTED: Rattus norvegicus similar to Vanin-3 (predicted) (VNN3_predicted), mRNA. |
|
Avpr1a |
1.42 |
1.70 |
AB, C |
25107 |
Rattus norvegicus arginine vasopressin receptor 1A (Avpr1a), mRNA. |
| Laptm4b |
0.94 |
1.68 |
AB |
315047 |
Rattus norvegicus lysosomal-associated protein transmembrane 4B (Laptm4b), mRNA. |
| Igf2bp3 |
1.23 |
1.67 |
AB, C |
312320 |
PREDICTED: Rattus norvegicus insulin-like growth factor 2, binding protein 3 (Igf2bp3), mRNA. |
| Aldh1b1 |
1.08 |
1.64 |
AB, C |
298079 |
Rattus norvegicus aldehyde dehydrogenase 1 family, member B1 (Aldh1b1), nuclear gene encoding mitochondrial protein, mRNA. |
|
Amy1a |
1.33 |
1.64 |
AB, C |
24203 |
Rattus norvegicus amylase, alpha 1A (salivary) (Amy1a), mRNA. |
| Aadac |
1.19 |
1.62 |
AB, C |
57300 |
Rattus norvegicus arylacetamide deacetylase (esterase) (Aadac), mRNA. |
|
Pipox |
1.56 |
1.60 |
AB, BC |
303272 |
Rattus norvegicus pipecolic acid oxidase (Pipox), mRNA. |
|
Sez6 |
1.28 |
1.58 |
AB, C |
192247 |
PREDICTED: Rattus norvegicus seizure related 6 homolog (mouse) (Sez6), mRNA. |
|
Olr59 |
1.31 |
1.56 |
AB, C |
170816 |
Rattus norvegicus olfactory receptor 59 (Olr59), mRNA. |
|
RGD1563713 |
1.31 |
1.56 |
AB |
316550 |
PREDICTED: Rattus norvegicus similar to Rab18 (RGD1563713), mRNA. |
|
Gpd2 |
1.28 |
1.56 |
AB, C |
25062 |
Rattus norvegicus glycerol-3-phosphate dehydrogenase 2, mitochondrial (Gpd2), nuclear gene encoding mitochondrial protein, mRNA. |
| Bche |
1.20 |
1.51 |
AB, C |
65036 |
Rattus norvegicus butyrylcholinesterase (Bche), mRNA. |
|
Otc |
1.32 |
1.51 |
AB, C |
25611 |
Rattus norvegicus ornithine carbamoyltransferase (Otc), nuclear gene encoding mitochondrial protein, mRNA. |
| Dnmt3b |
0.95 |
1.51 |
AB, AC, BC |
444985 |
Rattus norvegicus DNA methyltransferase 3B (Dnmt3b), mRNA. |
|
Clpx |
1.35 |
1.50 |
AB, BC |
300786 |
Rattus norvegicus ClpX caseinolytic peptidase X homolog (E. coli) (Clpx), mRNA. |
| Slc7a7 |
1.03 |
1.49 |
AB, C |
83509 |
Rattus norvegicus solute carrier family 7 (cationic amino acid transporter, y + system), member 7 (Slc7a7), mRNA. |
| Dpys |
1.04 |
1.49 |
AB, C |
65135 |
Rattus norvegicus dihydropyrimidinase (Dpys), mRNA. |
|
Fam82a |
1.34 |
1.48 |
AB, C |
313840 |
Rattus norvegicus family with sequence similarity 82, member A (Fam82a), mRNA. |
| Slc16a1 |
1.15 |
1.41 |
AB |
25027 |
Rattus norvegicus solute carrier family 16 (monocarboxylic acid transporters), member 1 (Slc16a1), mRNA. |
|
Adhfe1 |
1.32 |
1.40 |
AB, C |
362474 |
Rattus norvegicus alcohol dehydrogenase, iron containing, 1 (Adhfe1), mRNA. |
| Inhba |
1.10 |
1.40 |
AB, BC |
29200 |
Rattus norvegicus inhibin beta-A (Inhba), mRNA. |
| TMEM70 |
1.13 |
1.38 |
AB, C |
500384 |
PREDICTED: Rattus norvegicus similar to RIKEN cDNA 2210416 J16 (predicted) (TMEM70_predicted), mRNA. |
| RGD1560797 |
1.08 |
1.38 |
A, BC |
306115 |
PREDICTED: Rattus norvegicus similar to glyceraldehyde-3-phosphate dehydrogenase (predicted) (RGD1560797_predicted), mRNA. |
| RGD1310209 |
1.08 |
1.35 |
AB, C |
362019 |
PREDICTED: Rattus norvegicus similar to KIAA1324 protein (predicted) (RGD1310209_predicted), mRNA. |
| Maob |
1.24 |
1.34 |
AB |
25750 |
Rattus norvegicus monoamine oxidase B (Maob), nuclear gene encoding mitochondrial protein, mRNA. |
| Lrp5 |
1.09 |
1.34 |
AB |
293649 |
PREDICTED: Rattus norvegicus low density lipoprotein receptor-related protein 5 (predicted) (Lrp5_predicted), mRNA. |
| Klrg1 |
1.10 |
1.34 |
AB, C |
58975 |
Rattus norvegicus killer cell lectin-like receptor subfamily G, member 1 (Klrg1), mRNA. |
| Atf4 |
1.24 |
1.33 |
AB |
79255 |
Rattus norvegicus activating transcription factor 4 (tax-responsive enhancer element B67) (Atf4), mRNA. |
| Phf11 |
1.15 |
1.33 |
AB, C |
361051 |
PREDICTED: Rattus norvegicus PHD finger protein 11 (predicted) (Phf11_predicted), mRNA. |
| Rora |
1.25 |
1.33 |
AB |
300807 |
PREDICTED: Rattus norvegicus RAR-related orphan receptor alpha (predicted) (Rora_predicted), mRNA. |
| Serpina3m |
1.17 |
1.32 |
AB, C |
299276 |
PREDICTED: Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade A, member 3 M (Serpina3m), mRNA. |
| PLBD1 |
1.15 |
1.31 |
AB, C |
297694 |
Rattus norvegicus similar to RIKEN cDNA 1100001H23 (PLBD1), mRNA. |
| ANGPTL3 |
1.17 |
1.31 |
AB, C |
502970 |
PREDICTED: Rattus norvegicus similar to angiopoietin-related protein 3 (ANGPTL3), mRNA. |
| Agtr1a |
1.02 |
1.30 |
AB |
24180 |
Rattus norvegicus angiotensin II receptor, type 1 (AT1A) (Agtr1a), mRNA. |
| Apon |
1.09 |
1.30 |
AB, C |
304603 |
Rattus norvegicus apolipoprotein N (Apon), mRNA. |
| Lgals5 |
1.21 |
1.29 |
AB |
25475 |
Rattus norvegicus lectin, galactose binding, soluble 5 (Lgals5), mRNA. |
| Cabc1 |
1.23 |
1.28 |
AB |
360887 |
Rattus norvegicus chaperone, ABC1 activity of bc1 complex homolog (S. pombe) (Cabc1), nuclear gene encoding mitochondrial protein, mRNA. |
| Sdcbp |
1.12 |
1.27 |
AB |
83841 |
Rattus norvegicus syndecan binding protein (Sdcbp), mRNA. |
| CP |
1.07 |
1.27 |
AB |
294942 |
PREDICTED: Rattus norvegicus hypothetical CP (CP), mRNA. |
| Irf6 |
1.14 |
1.26 |
AB |
364081 |
PREDICTED: Rattus norvegicus interferon regulatory factor 6 (predicted) (Irf6_predicted), mRNA. |
| Hsd17b13 |
1.07 |
1.26 |
AB, C |
305150 |
PREDICTED: Rattus norvegicus hydroxysteroid (17-beta) dehydrogenase 13 (Hsd17b13), mRNA. |
| Mst1 |
1.17 |
1.26 |
AB |
24566 |
Rattus norvegicus Macrophage stimulating 1 (hepatocyte growth factor-like) (Mst1), mRNA. |
| Btg1 |
1.13 |
1.25 |
AB, C |
29618 |
Rattus norvegicus B-cell translocation gene 1, anti-proliferative (Btg1), mRNA. |
| MUT |
1.19 |
1.25 |
AB |
497857 |
PREDICTED: Rattus norvegicus similar to MYLE protein (Dexamethasone-induced protein) (predicted) (MUT_predicted), mRNA. |
|
Pxmp4 |
−1.38 |
−3.51 |
AB |
282634 |
Rattus norvegicus peroxisomal membrane protein 4 (Pxmp4), mRNA. |
|
Igfbp2 |
−2.11 |
−3.09 |
AB, C |
25662 |
Rattus norvegicus insulin-like growth factor binding protein 2 (Igfbp2), mRNA. |
|
Sds |
−1.54 |
−2.49 |
AB |
25044 |
Rattus norvegicus serine dehydratase (Sds), mRNA. |
|
Tnfsf13 |
−2.22 |
−2.42 |
AB |
287437 |
Rattus norvegicus tumor necrosis factor (ligand) superfamily, member 13 (Tnfsf13), mRNA. |
| Hnrpab |
−1.19 |
−2.09 |
AB, C |
83498 |
Rattus norvegicus heterogeneous nuclear ribonucleoprotein A/B (Hnrpab), mRNA. |
|
Asl |
−1.33 |
−2.07 |
AB, C |
59085 |
Rattus norvegicus argininosuccinate lyase (Asl), mRNA. |
|
Cd63 |
−1.36 |
−1.94 |
AB, C |
29186 |
Rattus norvegicus CD63 antigen (Cd63), mRNA. |
|
RGD1560687 |
−1.25 |
−1.85 |
AB, C |
500804 |
PREDICTED: Rattus norvegicus similar to Ferritin light chain (Ferritin L subunit) (predicted) (RGD1560687_predicted), mRNA. |
|
Trpm6 |
−1.27 |
−1.76 |
AB, C |
293874 |
PREDICTED: Rattus norvegicus transient receptor potential cation channel, subfamily M, member 6 (predicted) (Trpm6_predicted), mRNA. |
|
Hspb1 |
−1.34 |
−1.68 |
AB, C |
24471 |
Rattus norvegicus heat shock 27 kDa protein 1 (Hspb1), mRNA. |
| Ftl1 |
−1.11 |
−1.60 |
AB, C |
29292 |
Rattus norvegicus ferritin light chain 1 (Ftl1), mRNA. |
|
Mgst2 |
−1.43 |
−1.54 |
AB, BC |
295037 |
PREDICTED: Rattus norvegicus microsomal glutathione S-transferase 2 (predicted) (Mgst2_predicted), mRNA. |
| Znf593 |
−1.19 |
−1.53 |
AB, C |
298546 |
PREDICTED: Rattus norvegicus zinc finger protein 593 (predicted) (Znf593_predicted), mRNA. |
|
Ppcs |
−1.43 |
−1.52 |
AB, C |
298490 |
Rattus norvegicus phosphopantothenoylcysteine synthetase (Ppcs), mRNA. |
|
Mthfd1 |
−1.38 |
−1.47 |
A, BC |
64300 |
Rattus norvegicus methylenetetrahydrofolate dehydrogenase (NADP + dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (Mthfd1), mRNA. |
|
Pmm1 |
−1.26 |
−1.47 |
A, B, C |
300089 |
Rattus norvegicus phosphomannomutase 1 (Pmm1), mRNA. |
|
Aqp11 |
−1.35 |
−1.45 |
AB |
286758 |
Rattus norvegicus aquaporin 11 (Aqp11), mRNA. |
|
Csrp2 |
−1.34 |
−1.45 |
A, B, C |
29317 |
Rattus norvegicus cysteine and glycine-rich protein 2 (Csrp2), mRNA. |
|
Pla2g12a |
−1.27 |
−1.44 |
AB, BC |
362039 |
PREDICTED: Rattus norvegicus phospholipase A2, group XIIA (predicted) (Pla2g12a_predicted), mRNA. |
| Tifa |
−1.24 |
−1.42 |
AB, C |
310877 |
Rattus norvegicus TRAF-interacting protein with forkhead-associated domain (Tifa), mRNA. |
| Hexb |
−1.17 |
−1.41 |
AB, C |
294673 |
Rattus norvegicus hexosaminidase B (Hexb), mRNA. |
| Rps14 |
−1.15 |
−1.41 |
AB, C |
29284 |
Rattus norvegicus ribosomal protein S14 (Rps14), mRNA. |
|
Ier3 |
−1.38 |
−1.40 |
AB |
294235 |
Rattus norvegicus immediate early response 3 (Ier3), mRNA. |
|
Paics |
−1.40 |
−1.40 |
AB |
140946 |
Rattus norvegicus phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (Paics), mRNA. |
|
Txnl5 |
−1.32 |
−1.38 |
AB |
287474 |
PREDICTED: Rattus norvegicus thioredoxin-like 5 (predicted) (Txnl5_predicted), mRNA. |
|
Pla1a |
−1.35 |
−1.38 |
AB |
85311 |
Rattus norvegicus phospholipase A1 member A (Pla1a), mRNA. |
| Cyp8b1 |
−1.08 |
−1.37 |
AB, C |
81924 |
Rattus norvegicus cytochrome P450, family 8, subfamily b, polypeptide 1 (Cyp8b1), mRNA. |
|
Creb3 |
−1.28 |
−1.36 |
AB, C |
298400 |
Rattus norvegicus cAMP responsive element binding protein 3 (Creb3), mRNA. |
| Cd320 |
−1.06 |
−1.36 |
AB, C |
362851 |
PREDICTED: Rattus norvegicus CD320 antigen (Cd320), mRNA. |
| Nola2 |
−1.10 |
−1.34 |
AB, C |
287273 |
PREDICTED: Rattus norvegicus nucleolar protein family A, member 2 (predicted) (Nola2_predicted), mRNA. |
| Sult1c1 |
−0.87 |
−1.32 |
AB |
65185 |
Rattus norvegicus sulfotransferase family, cytosolic, 1C, member 1 (Sult1c1), mRNA. |
| Slc11a2 |
−1.16 |
−1.32 |
AB, BC |
25715 |
Rattus norvegicus solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2), mRNA. |
| Btbd9 |
−1.19 |
−1.31 |
A, BC |
294318 |
Rattus norvegicus BTB (POZ) domain containing 9 (Btbd9), mRNA. |
| Htatip2 |
−1.20 |
−1.30 |
AB, C |
292935 |
PREDICTED: Rattus norvegicus HIV-1 tat interactive protein 2, homolog (human) (predicted) (Htatip2_predicted), mRNA. |
| Ctsl1 |
−1.09 |
−1.29 |
AB, C |
25697 |
Rattus norvegicus cathepsin L1 (Ctsl1), mRNA. |
| Psmb3 |
−1.14 |
−1.29 |
AB, C |
29676 |
Rattus norvegicus proteasome (prosome, macropain) subunit, beta type 3 (Psmb3), mRNA. |
| Sat2 |
−1.16 |
−1.29 |
AB |
360547 |
PREDICTED: Rattus norvegicus spermidine/spermine N1-acetyl transferase 2 (predicted) (Sat2_predicted), mRNA. |
| Gtf2b |
−1.15 |
−1.29 |
AB, C |
81673 |
Rattus norvegicus general transcription factor IIB (Gtf2b), mRNA. |
| Eppb9 |
−1.10 |
−1.26 |
AB, BC |
287383 |
PREDICTED: Rattus norvegicus endothelial precursor protein B9 (predicted) (Eppb9_predicted), mRNA. |
| Sdf2 |
−1.05 |
−1.26 |
AB |
287470 |
PREDICTED: Rattus norvegicus stromal cell derived factor 2 (predicted) (Sdf2_predicted), mRNA. |
| Wdr45 |
−1.17 |
−1.26 |
AB, C |
302559 |
Rattus norvegicus WD repeat domain 45 (Wdr45), mRNA. |
| Psma5 | −1.20 | −1.26 | AB, C | 29672 | Rattus norvegicus proteasome (prosome, macropain) subunit, alpha type 5 (Psma5), mRNA. |
Bold indicates genes where the expression change in the UN/Sal/Chow cohort (predisposed to metabolic syndrome) is also at least 1.25 fold, indicating that precursor changes are occurring in this group also. Additional file 5: Table S5 is an expanded version of this table containing further annotation relating to gene ontology, gene function and known human diseases related to these genes.