Table 1.
Association of GATA4 gene variants with coronary artery disease, myocardial infarction congenital heart disease
| Block | Haplotype | Pooled | Cases | Control | χ 2 | p value |
|---|---|---|---|---|---|---|
| Hypercholesterolaemia |
|
|
|
|
|
|
| 1–9 |
AACCCATGT |
0.063 |
0.071 |
0.060 |
3.86 |
0.050 |
| 5–10 |
CATGTC |
0.088 |
0.096 |
0.082 |
4.25 |
0.039 |
| High low-density lipoprotein |
|
|
|
|
|
|
| 1–10 |
AACCCATGTC |
0.062 |
0.079 |
0.062 |
4.83 |
0.028 |
| |
GACCCATGCC |
0.015 |
0.024 |
0.015 |
4.94 |
0.026 |
| 1–9 |
AACCCATGT |
0.063 |
0.078 |
0.062 |
4.31 |
0.038 |
| Hypertriglyceridaemia |
|
|
|
|
|
|
| 2–7 |
ACACAT |
0.083 |
0.072 |
0.088 |
4.79 |
0.029 |
| 2–6 |
ACCTA |
0.013 |
0.018 |
0.011 |
4.65 |
0.031 |
| 3–6 |
CCTA |
0.016 |
0.021 |
0.014 |
4.34 |
0.037 |
| 1–5 |
AACCT |
0.01 |
0.015 |
0.009 |
4.49 |
0.034 |
| Hypertension |
|
|
|
|
|
|
| 1–8 |
GACCCACG |
0.02 |
0.018 |
0.026 |
4.26 |
0.039 |
| 1–6 |
GACCCA |
0.103 |
0.098 |
0.119 |
6.78 |
0.009 |
| Type 2 diabetes mellitus |
|
|
|
|
|
|
| 1–9 |
GACACACCC |
0.18 |
0.192 |
0.175 |
4.05 |
0.044 |
| Obesity |
|
|
|
|
|
|
| 1–10 |
GACCCGCGCC |
0.025 |
0.032 |
0.022 |
7.59 |
0.006** |
| |
GACCCGCGC |
0.026 |
0.033 |
0.022 |
7.42 |
0.006** |
| 2–10 |
ACCCGCGCC |
0.026 |
0.031 |
0.022 |
6.55 |
0.011 |
| 3–10 |
CCCGCGCC |
0.026 |
0.031 |
0.022 |
6.55 |
0.011 |
| 1–8 |
GACCCGCG |
0.028 |
0.033 |
0.024 |
5.27 |
0.022 |
| 1–7 |
GACCCGC |
0.028 |
0.033 |
0.024 |
6.14 |
0.013 |
| 4–10 |
CCGCGCC |
0.026 |
0.031 |
0.022 |
5.97 |
0.015 |
| 3–9 |
CCCGCGC |
0.027 |
0.033 |
0.023 |
6.88 |
0.009 |
| 2–8 |
ACCCGCG |
0.028 |
0.033 |
0.025 |
4.53 |
0.033 |
| 3–8 |
CCCGCG |
0.027 |
0.032 |
0.024 |
5.23 |
0.022 |
| 3–7 |
CCCGC |
0.029 |
0.034 |
0.025 |
5.33 |
0.021 |
| 5–9 | CGCGC | 0.030 | 0.035 | 0.026 | 5.08 | 0.024 |
The table shows selected haplotypes associated with the disease. The most frequent 10-mer haplotype (0.14) was employed as the baseline to determine the relative effects of the other haplotypes. The studied SNPs are rs2740434 (also denoted as 1), rs17153743 (2), rs13264774 (3), rs56298569 (4), rs804280 (5), rs3729855 (6), rs3729856 (7), rs1062219 (8), rs11785481 (9) and rs3203358 (10) arranged sequentially by their chromosomal positions, whereby blocks represent the range of variants constituting the respective haplotypes. *p < 0.01; **p < 0.005 by χ2 test.