Table 3.
Association of GATA4 haplotypes with coronary artery disease/myocardial infarction
|
Variant |
Genotype/allele |
Controls |
Cases |
Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|---|---|---|
| p value | Exp (B)(95% CI) | Corrected p value | Exp (B″)(95% CI) | ||||
| Hypercholesterolaemia | |||||||
| rs804291CT |
TT |
0.016 |
0.027 |
0.023* |
1.66(1.07–2.57) |
0.037* |
1.61(1.03–2.52) |
| rs11785481CT |
CT + TT |
0.196 |
0.220 |
0.065 |
1.16(0.99–1.34) |
0.087 |
1.15(0.98–1.35) |
| rs3203358CG |
CG + GG |
0.358 |
0.323 |
0.020* |
0.85(0.75–0.98) |
0.026* |
0.86(0.75–0.98) |
| Hypertriglyceridaemia | |||||||
| rs3729855CT |
T |
0.030 |
0.041 |
0.023 |
1.35(1.01–1.78) |
0.004** |
1.49(1.14–1.94) |
| CT + TT |
0.053 |
0.070 |
0.005** |
1.34(1.09–1.64) |
0.010* |
1.47(1.10–1.96) |
|
| rs1062219CT |
TT |
0.220 |
0.182 |
0.011* |
0.79(0.67–0.98) |
0.016* |
0.80(0.67–0.99) |
| Elevated low-density lipoprotein-cholesterol | |||||||
| rs804291CT |
TT |
0.018 |
0.033 |
0.016* |
1.90(1.13–3.21) |
0.020* |
1.87(1.10–3.15) |
| rs11785481CT |
CT + TT |
0.201 |
0.229 |
0.032* |
1.18(1.01–1.37) |
0.136 |
1.18(0.95–1.45) |
| Low high-density lipoprotein-cholesterol | |||||||
| rs2740434CT |
CT + TT |
0.084 |
0.069 |
0.013* |
0.81(0.69–0.96) |
0.744 |
0.93(0.62–1.41) |
| Hypertension | |||||||
| rs3729855CT |
T |
0.027 |
0.035 |
0.089 |
1.30(0.95–1.77) |
0.013* |
1.52(1.09–2.11) |
| rs17153743AG |
AG + GG |
0.017 |
0.031 |
0.022* |
1.87(1.10–3.18) |
0.005* |
2.30(1.30–4.26) |
| rs13264774CT |
T |
0.041 |
0.024 |
0.008* |
0.59(0.40–0.87) |
0.085 |
0.68(0.44–1.05) |
| Type 2 diabetes mellitus | |||||||
| rs3729855CT |
T |
0.040 |
0.028 |
0.003* |
0.70(0.55–0.89) |
0.003* |
0.68(0.53–0.88) |
| rs13264774CT |
CT + TT |
0.035 |
0.023 |
0.025* |
0.66(0.045–0.95) |
0.199 |
0.76(0.51–1.16) |
| Obesity | |||||||
| rs17153743AG |
GG |
0.138 |
0.070 |
0.031 |
0.73(0.55–0.98) |
0.357 |
0.94(0.82–1.07) |
| rs11785481CT |
TT |
0.029 |
0.022 |
0.033* |
0.73(0.55–0.98) |
0.903 |
0.84(0.73–0.95) |
| rs2740434GA | GA + AA | 0.086 | 0.065 | 0.013* | 0.73(0.50–0.94) | 0.011* | 0.72(0.56–0.93) |
The table summarizes the univariate and multivariate analyses for the relationships of the gene variants with various cardiovascular disease traits. Bonferroni tests have been performed to adjust for age and sex and adjustment made for the confounders in the multivariate tests. *p < 0.05; **p < 0.005.