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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Lancet Respir Med. 2013 Jun 28;1(6):453–461. doi: 10.1016/S2213-2600(13)70101-2

Figure 1. Cohort members at higher genetic risk were more likely to develop asthma ever and did so earlier in life.

Figure 1

Children at higher genetic risk were more likely to develop asthma through age 38 years and did so earlier in life (Hazard Ratio (HR)=1.12 [1.01–1.26]). Hazards were estimated using a Cox regression model testing association between the continuous genetic risk score and timing of asthma onset. The Cox model was adjusted for sex. Panel A plots Kaplan-Meier Survival Curves for asthma onset among girls and boys in the Dunedin cohort. Panels B and C plot the same data separately for girls and boys with genetic risk scores below the cohort mean (low genetic risk) and cohort members with genetic risk scores above the cohort mean (high genetic risk). Risk tables provide number at risk at birth and ages 7, 15, 21, 26, 32, and 38 years.