Table 2.
miRNAs and the hallmarks of cervical cancer.
| Hallmarks | Functions of miRNAs | miRNAs |
|---|---|---|
| Regulation of cell proliferation | Proproliferation | miR-10a, miR-15b, miR-17, miR-19a/b, miR-21, miR-34a, miR-129, miR-146a, miR-148a, miR-196, miR-210, miR-223, and miR-301b. |
| Antiproliferation | let-7, miR23b, miR-26a, miR-101, miR-143, miR-145, miR-196b, 199a, miR-203, miR-424, and miR-519. | |
|
| ||
| Regulation of apoptosis | Proapoptosis | miR-34a, miR-10b, miR-29a, miR-99a, and miR-195. |
| Antiapoptosis | miR-17, miR-21, miR-149, miR-182, miR-203, miR-433, and miR-497. | |
|
| ||
| Regulation of limitless replicative potential | Regulation of immortalization or senescence | miR-24 and miR-34a. |
|
| ||
| Regulation of angiogenesis | Proangiogenesis | let-7, miR-17, miR-20a, miR-21, miR-23b, miR-26a, miR29a, miR-126, miR133a, miR-183, miR-210, and miR-214. |
| Antiangiogenesis | miR-15b, miR-16, miR-20a, miR-26a, miR-143, miR-145, miR-424, and miR497. | |
|
| ||
| Regulation of immune responses | Escape from immunosurveillance | miR-155, miR-17, miR-23b, miR-26a, miR-29a, miR-17, miR-20a, miR-21, miR-93, and miR-106b. |
|
| ||
| Regulation of tumor invasion and metastasis | Prometastasis | miR-10a, miR-19a/b, miR-21, miR-23b, miR-106b, miR135, miR-155, and miR-214. |
| Antimetastasis | let-7, miR-101, miR-126, miR-146a, miR-200, and miR-218. | |
|
| ||
| Regulation of genomic instability | Promote genomic instability | let-7,miR-15, miR-16, miR-17, and miR20a. |
Information obtained from microRNA.org-Targets and Expression. miRNAs in bold were experimentally validated in cervical cancer; underlined miRNAs were experimentally validated in other cancers.