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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Immunol. 2013 Dec 30;192(3):1055–1063. doi: 10.4049/jimmunol.1302694

Figure 5.

Figure 5

The effect of Id proteins on Vδ6.3+ γδ T cells is mediated by E proteins and is developmental stage-specific. (A) Although conditional knockout of both Id2 and Id3 limits the accumulation of Vδ6.3+ γδ T cells in the thymus, further deletion of HEB and/or E2A can restore the accumulation of those cells. N≥3 for each group. (B) Deletion of all alleles of HEB, E2A, Id2 and Id3 by CD4Cre can induce accumulation of Vδ6.3+ γδ T cells, but deletion by LckCre fails to induce a similar phenotype. N≥3 for each group. All error bars indicate SD.