Table 3. LRs for 3-year death from OPSCC.
|
Prognostic values for prediction of death from OPSCC at 3 years |
||||||
|---|---|---|---|---|---|---|
|
HPV-positive OPSCC |
HPV-negative OPSCC |
|||||
| DR % (21 deaths) | FPR % (95 alive) | LR | DR % (41 deaths) | FPR % (53 alive) | LR | |
|
Age, years | ||||||
| ⩾50 | 57.1 | 72.6 | 0.79 | 85.4 | 81.1 | 1.05 |
| ⩾55 | 47.6 | 51.6 | 0.92 | 73.2 | 58.5 | 1.25 |
| ⩾60 |
47.6 |
30.5 |
1.56 |
61.0 |
35.8 |
1.70 |
|
Gender | ||||||
| Male |
81.0 |
66.3 |
1.22 |
85.4 |
62.3 |
1.37 |
|
Smoking | ||||||
| Smoker >10/day |
77.8 |
27.9 |
2.78 |
71.4 |
66.7 |
1.07 |
|
Alcohol | ||||||
| Drinker |
72.2 |
86.1 |
0.84 |
75.9 |
87.5 |
0.86 |
|
Stage | ||||||
| ⩾II, III, IV | 100.0 | 97.9 | 1.02 | 97.6 | 73.6 | 1.33 |
| ⩾III, IV | 95.2 | 93.7 | 1.02 | 80.5 | 56.6 | 1.42 |
| IV |
90.5 |
76.8 |
1.18 |
68.3 |
41.5 |
1.65 |
|
T stage | ||||||
| >T3, T4 |
57.1 |
23.4 |
2.44 |
43.9 |
28.8 |
1.52 |
|
Nodal metastases | ||||||
| Yes |
95.2 |
88.4 |
1.08 |
78.0 |
45.3 |
1.72 |
|
N stage | ||||||
| >N2b |
76.2 |
49.5 |
1.54 |
58.5 |
30.2 |
1.94 |
|
Differentiation | ||||||
| Moderate, poor | 95.2 | 98.9 | 0.96 | 100.0 | 98.1 | 1.02 |
| Poor |
66.7 |
74.7 |
0.89 |
53.7 |
34.0 |
1.58 |
|
EGFR | ||||||
| Positive |
66.7 |
52.6 |
1.27 |
78.0 |
75.5 |
1.03 |
|
TILs | ||||||
| Low, moderate | 90.0 | 46.8 | 1.92 | 85.4 | 84.9 | 1.01 |
| Low | 35.0 | 10.6 | 3.30 | 53.7 | 41.5 | 1.29 |
Abbreviations: DR=detection rate; FPR=false-positive rate; HPV=human papillomavirus; LR=likelihood ratio; OPSCC=oropharyngeal cancer; TIL=tumour-infiltrating lymphocyte.