Table 1. List of the top 15 differentially up or downregulated genes following CHKA silencing.
| Gene symbol | Parametric P-value | FDRa | Geometric mean of intensitiesb | |
|---|---|---|---|---|
| CHKA |
4.60E-06 |
0.0421 |
0.44 |
Downregulated genes |
| CCNA1 |
2.60E-06 |
0.0421 |
0.48 |
|
| KRT80 |
0.0005081 |
0.128 |
0.51 |
|
| IL6 |
0.0046555 |
0.213 |
0.51 |
|
| TAGLN |
0.0064673 |
0.236 |
0.53 |
|
| IL8 |
9.30E-06 |
0.0467 |
0.54 |
|
| AKAP12 |
0.0009146 |
0.145 |
0.56 |
|
| H19 |
3.29E-05 |
0.106 |
0.59 |
|
| IDH2 |
5.34E-05 |
0.106 |
0.59 |
|
| TNFRSF25 |
0.0011795 |
0.148 |
0.61 |
|
| KRT7 |
0.0016046 |
0.163 |
0.61 |
|
| LIMK1 |
0.0054187 |
0.222 |
0.61 |
|
| MAD2L1 |
8.14E-05 |
0.124 |
0.62 |
|
| SEC23A |
0.0001111 |
0.124 |
0.62 |
|
| SNX25 |
0.0007806 |
0.137 |
0.62 |
|
| ARFIP1 |
0.0009437 |
0.146 |
1.57 |
Upregulated genes |
| CA5B |
0.0022191 |
0.169 |
1.57 |
|
| LAMC1 |
0.0002072 |
0.124 |
1.59 |
|
| C5 |
0.0013041 |
0.155 |
1.6 |
|
| PRSS35 |
0.0004709 |
0.128 |
1.62 |
|
| SPTLC3 |
0.0002098 |
0.124 |
1.63 |
|
| UBE2E3 |
4.63E-05 |
0.106 |
1.64 |
|
| BCMO1 |
0.0001368 |
0.124 |
1.64 |
|
| ID3 |
0.0032983 |
0.19 |
1.67 |
|
| PPAP2A |
0.0001578 |
0.124 |
1.71 |
|
| LRRC31 |
0.0001612 |
0.124 |
1.72 |
|
| RTN4 |
3.78E-05 |
0.106 |
1.76 |
|
| FXYD2 |
0.0025975 |
0.175 |
1.84 |
|
| TNFRSF11B |
0.0001958 |
0.124 |
1.85 |
|
| ACSM3 | 4.54E-05 | 0.106 | 2.11 |
a
FDR, false discovery rate.
b
For each specified probe represents the ratio between the mean intensity of the siCHKA vs control cells.