Table 2. Parameter estimates for gemcitabine pharmacokinetic model.
| Parameter (unit) | Estimate (RSE%) | Bootstrap median (95% CI) |
|---|---|---|
| CLgem (l h−1 1.76 m−2) |
425.0 (7.44) |
419.3 (361.8, 485.8) |
| NT5C2 on CLgem |
0.816 (8.49) |
0.823 (0.689, 0.938) |
|
VC-gem (l 1.76 m−2 per 70 years) |
114.0 (6.00) |
114.8 (102.1, 127.3) |
| Exponent of AGE on VC-gem |
−0.340 (39.7) |
−0.337 (−0.765, 0.07) |
| Q1 (l h−1) |
10.1 (28.6) |
10.9 (6.2, 23.4) |
|
VP-gem (l) |
101.0 (50.5) |
110.3 (39.5, 447.4) |
| IIV—CLgem |
22.2 (32.8) |
21.3 (14.7, 29.7) |
| IIV—VC-gem |
12.9 (65.1) |
11.5 (0.5, 21.5) |
| IIV—Q1 |
97.6 (31.2) |
92.6 (60.9, 124.3) |
| IIV—VP-gem |
87.5 (38.9) |
61.6 (0.3, 114.5) |
| RUV (CV%) | 24.9 (16.9) | 24.9 (21.4, 28.9) |
Abbreviations: CI=confidence interval; IIV=inter-individual variability, expressed as CV% RSE=relative s.e., expressed as CV% RUV=random unexplained variability, expressed as CV%.