Table 3. Parameter estimates for dFdU pharmacokinetic model.
| Parameter (units) | Estimate (RSE%) | Bootstrap median (95% CI) |
|---|---|---|
| CLedFdU (l h−1 per CLCR 75 ml min−1) |
3.04 (11.2) |
3.05 (2.42, 3.63) |
| CDA on CLedFdU |
1.43 (13.2) |
1.43 (1.14, 1.86) |
|
VC-dFdU (l 1.76 m−2) |
16.1 (15.7) |
16.1 (10.7, 21.9) |
| Q2 (l h−1) |
70.4 (13.5) |
70.7 (49.4, 90.6) |
| Q3 (l h−1) |
32.6 (7.39) |
32.9 (29.0, 37.8) |
|
VP1-dFdU (l) |
6.36 (8.77) |
6.29 (5.27, 7.55) |
|
VP2-dFdU (l) |
113 (10.1) |
112.8 (93.6, 135.6) |
| IIV—CLedFdU |
41.2 (30.9) |
40.3 (30.4, 53.3) |
| IIV—VC-dFdU |
62.9 (31.3) |
61.7 (43.8, 83.4) |
| IIV—VP1-dFdU |
34.9 (27.4) |
34.6 (25.6, 48.1) |
| IIV—VP2-dFdU |
54.6 (35.6) |
52.2 (29, 69.0) |
| RUV | 9.89 (32.8) | 9.8 (7.5, 12.6) |
Abbreviations: CI=confidence interval; IIV=inter-individual variability, expressed as CV% RSE=relative s.e., expressed as CV% RUV=random unexplained variability, expressed as CV%.