Table 4. Parameter estimates for dFdCTP pharmacokinetic model.
| Parameter | Estimate | Bootstrap median (95% CI) |
|---|---|---|
| CLfdFdCTP (l h−1) ROI<25 |
0.118 |
0.128 (0.071, 0.235) |
| CLfdFdCTP (l h−1) ROI>25 |
0.061 |
0.065 (0.041, 0.101) |
| SLC28A3 on CLfdFdCTP |
1.77 |
1.78 (1.10, 2.56) |
| CLedFdCTP (l h−1) |
0.00131 |
0.00152 (0.0007, 0.0023) |
|
VC-dFdCTP (l) |
0.005 |
— |
| Q2 (l h−1) |
0.206 |
0.27 (0.077, 0.774) |
| Q3 (l h−1) |
0.00126 |
0.0014 (0.0008, 0.0023) |
|
VP1-dFdCTP (l) |
0.0288 |
0.029 (0.017, 0.048) |
|
VP2-dFdCTP (l) |
0.0877 |
0.078 (0.017, 0.221) |
| IIV—CLfdFdCTP |
54.6 |
51.9 (37.2, 64.3) |
| IIV—VP1-dFdCTP |
36.9 |
38.7 (17.5, 59.8) |
| IIV—Q2 |
186 |
194.2 (124.9, 270.4) |
| RUV-proportional (CV%) |
32.2 |
31.9 (27.7, 35.4) |
| RUV-additive (s.d.) | 1.33 | 1.33 (0.725, 1.39) |
Abbreviations: CI=confidence interval; CV=coefficient of variation; IIV=inter-individual variability, expressed as CV% ROI=rate of infusion of gemcitabine, expressed as mg m−2 min−1; RUV=random unexplained variability, expressed as CV% s.d.=standard deviation.