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Delayed OL differentiation and maturation following conditional ablation of Nkx2.2 in OPCs. Spinal cord sections from Cnp+/cre;Nkx2.2+/fl and Cnp+/cre;Nkx2.2fl/fl were subjected to Mbp (A-D′) and Plp (E-H′) in situ hybridization at P3, P7, P13 and P21.