Table 5.

Results for loci previously associated with overall advanced age-related macular degeneration (AMD) in the choroidal neovascularization (CNV) vs. no AMD and geographic atrophy (GA) vs. no AMD analyses

Locus	SNP	CNV vs. no AMD				GA vs. no AMD
		OR	L95	U95	P value	OR	L95	U95	P value
ARMS2/HTRA1	rs10490924	3.67	3.33	4.05	1.5× 10−138	2.52	2.24	2.83	7.1× 10−47
CFH	rs1061170	0.36	0.33	0.40	1.2× 10−108	0.36	0.32	0.40	4.8× 10−67
CFB	rs641153	0.45	0.38	0.54	1.0× 10−17	0.47	0.37	0.59	1.5× 10−9
C3	rs2230199	1.61	1.40	1.85	1.0× 10−12	1.83	1.56	2.14	4.9× 10−13
CFI	rs10033900	1.31	1.19	1.44	6.4× 10−9	1.32	1.17	1.48	3.9× 10−6
C2	rs9332739	0.48	0.37	0.62	1.2× 10−6	0.38	0.26	0.56	1.2× 10−6
CETP	rs3764261	1.22	1.12	1.33	6.5× 10−6	1.06	0.95	1.19	0.30
FRK/COL10A1	rs1999930	0.82	0.75	0.90	4.1× 10−5	0.78	0.69	0.89	1.4× 10−4
TIMP3	rs9621532	1.55	1.25	1.93	8.0× 10−5	1.16	0.90	1.51	0.25
VEGFA	rs4711751	1.20	1.09	1.33	2.0× 10−4	1.23	1.08	1.40	0.002
LIPC	rs10468017	0.83	0.75	0.91	2.4× 10−4	0.84	0.73	0.96	0.008
ABCA1	rs1883025	0.86	0.78	0.95	0.002	0.88	0.78	0.99	0.048
COL8A1	rs13095226	0.83	0.73	0.95	0.006	0.78	0.66	0.92	0.0036

GA= geographic atrophy, AMD= age-related macular degeneration, CNV=choroidal neovascularization, SNP = single nucleotide polymorphism, OR= odds ratios, L95 = lower 95% confidence interval, U95= upper 95% confidence interval