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. 2012 May 29;3(2):320–343. doi: 10.3390/genes3020320

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Examples of mechanisms by which bromodomain proteins regulate gene expression in budding yeast. (a) The bromodomain of Gcn5 binds to acetylated H3 and anchors the histone acetyltransferase complex Spt-Ada-Gcn5 acetyltransferase(SAGA) to nucleosomes, allowing SAGA to acetylate adjacent nucleosomes. The chromatin remodeling complex SWI/SNF then binds to the acetylated nucleosomes and remodels the promoter region to allow for formation of the pre-initation complex and ultimately transcription; (b) The bromodomain-extraterminal (BET) bromodomain protein Bdf1 binds to acetylated H4 and recruits the general transcription factor TFIID.