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. 2012 Jul 23;3(3):444–460. doi: 10.3390/genes3030444

Figure 2.

Figure 2

EWS/ETS fusions in Ewing sarcoma. EWS/FLI fusions comprise 80–85% of all translocations in Ewing sarcoma. Translocations involving other ETS family members such as ERG, ETV4, ETV1 and FEV1 are less common. In all instances, the transcriptional activating domain (TAD) in the N-terminus of EWS is fused to the C-terminal DNA binding domain (DBD) of the ETS family member. The resultant chimeric fusion protein functions as a potent oncogenic transcription factor responsible for tumorigenesis in Ewing sarcoma.