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FRH stabilizes the IDP FRQ thereby supporting the normal oscillator cycle. Schematic representation of the role of FRH: If FRQ can bind to FRH, FRH is able to stabilize FRQ throughout its functional cycle of interactions and progressive phosphorylations until it is targeted by FWD-1 for the ubiquitylations that will lead to its degradation in the proteasome. If FRQ cannot bind to FRH, FRQ remains highly unstable and is targeted for degradation as soon as translation is complete.
