Figure 2.

(a) A synXPC micro-CT image (4.5 μm thick virtual sections of the three-dimensional reconstruction) of the tibial epiphysis from a healthy naive adult mouse (C57BL/6, 12 weeks old) compared with (b) a CAXPC image (single two-dimensional projection) of a 1 mm thick coronal section of the tibial epiphysis imaged from a healthy naive adult rat (Sprague–Dawley, 12 weeks old). The surface of the articular cartilage is similarly clearly demarcated in both images (white arrowheads), whereas the deeper cartilage presents limited features (similar to the background). The bottom edge of the articular cartilage correctly, in both images, corresponds with the upper edge of the calcified cartilage (also known as the ‘tidemark’). The subchondral bone features (asterisks) appear strongly contrasted over the bone marrow (M) background.