TABLE 1.
Inducer | Source of inducer | Cyp subfamily induced |
---|---|---|
Nonhalogenated polycyclic aromatic hydrocarbons | Petroleum derivatives and coal-tar constituents | CYP1A |
Polyhalogenated aromatic hydrocarbons dioxins | Forest fires, volcano activities, industrial processes, waste incretion | Predominately CYP1A or predominately CYP2B or mixed |
DDT, dieldrin, chlordane, and mirex | Chlorinated hydrocarbon pesticides | CYP2B and to a lesser extent the CYP3A |
CYP - cytochrome P450; DDT - dichlorodiphenyltrichloroethane