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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Immunol. 2013 Dec 27;192(3):919–928. doi: 10.4049/jimmunol.1301979

Figure 9. Specific deletion of Lyn and MyD88 in B cells prevents the development of pathogenic class-switched autoantibodies and autoimmunity.

Figure 9

(A-D) Detection of autoreactive IgM-isotype (A), IgG-isotype (B) and pathogenic class-switched IgG anti-dsDNA (C) or anti-sm/RNP (D) antibodies in the serum of 8- month-old control, B-lyn−/− and B-lyn−/− myd88−/− mice. Bars represent mean ± SEM from 6 mice per group. * P ≤ 0.05, ** P ≤ 0.01, ** P ≤ 0.001 (One-way ANOVA).

(E) H&E, C3 and IgG staining of kidney sections from 8 month-old B-lyn−/− myd88−/− mice. Representative pictures are shown. Scale bars represent 50 μm.