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. Author manuscript; available in PMC: 2014 Dec 5.
Published in final edited form as: Cell Stem Cell. 2013 Dec 5;13(6):720–733. doi: 10.1016/j.stem.2013.10.003

Fig. 1. Inducible postnatal ectopic expression of Dkk1, or deletion of epithelial β-catenin causes rapid regression of anagen HFs.

Fig. 1

(A) Schematic of HF growth cycle and structure. Light blue arrows indicate stem cell self-renewal. Dark blue arrows indicate cell movements. (B–P) Krt5-rtTA tetO-Cre Ctnnb1fl/fl mutants, Dkk1 transgenics and Dkk1/Krm1 transgenics, and their respective littermate controls were induced from P4 (B–K) or P7 (L–P) and H&E stained skin sections photographed at the stages indicated. Arrow (M) indicates structural abnormalities in β-catenin mutant HF. Insets in (L–P) represent higher magnification photographs. Scale bars: (B–K) 200 µm and (L–P) 100 µm. See also Fig. S1.