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. Author manuscript; available in PMC: 2014 Dec 17.
Published in final edited form as: Anal Chem. 2013 Nov 26;85(24):11677–11680. doi: 10.1021/ac402764x

Figure 1.

Figure 1

Normalized metabolic responses for 0.5 μL dye/mL SYTO dye 13 exposure to pheochromocytoma (PC-12) cells. Basal baseline measurements were obtained 10 min prior to exposure, with standard error variation in the baseline follows: glucose ± 27.1% (−8 to 0 min time points used for baseline), lactate ± 1.90%, oxygen ± 3.80%, and acidification ± 0.34%. The SYTO dye was administered for thirty minutes during the experiment, as indicated by the black line on the horizontal axis of the graph. Afterwards, running media was applied for a 60 min recovery period. Significant increases in lactate production and extracellular acidification suggest the increasing utilization of the anaerobic respiratory pathways for ATP production. Decreases in glucose and oxygen consumption highlight the impairment of the aerobic respiratory pathway by SYTO dye exposure.