Table 3.

Results of localizing studies and tumor location

Localized:
Subject Number	Octreotide	FDG PET/CT	Venous Sampling	Tumor Location	Histopathological Diagnosis
1	+	ND	− 1	Right maxilla	Infiltrative spindle cell and vascular lesion consistent with PMT
2	+	ND	ND	Left forearm with pulmonary metastases	Spindle cell sarcoma with focal collection of giant cells, consistent with PMT
3	+	ND	ND	Left ethmoid sinus	Hemangiopericytoma
5*	+	+	+	Left heel fat pad	PMT composed of spindle cells, clusters of osteoclast-like giant cells, and foci of cartilaginous metaplasia
6	+	+	ND	Right mandible with pulmonary metastases	Spindle cell tumor consistent with PMT (mandible); Features consistent with PMT and ameloblastic fibrosarcoma (metastases) (ref. 15)
10	+	+	ND	Left lateral femoral condyle	PMT
11 *	+	+	+	Left thigh	Angiolipoma with clear cells as well as pleomorphic features associated with PMT
13 *	+	+	+	Left fibula	Spindle cell neoplasm with features of PMT
14		+	− 2	T8 vertebral body	PMT (vertebral body tumor); atypical spindle and polygonal cells with enlarged, elongated nuclei and osteoclasts
15	+	+	+	Left acetabulum	Fragmented portions of bone showing spindle cell neoplasm highly suggestive of PMT
16	ND3	+	ND	Left lower back subcutaneous nodule	Tumor nodule in deep dermis comprised of spindle cells, vascular spaces, and bone formation consistent with PMT
19	+	+	+	Left greater trochanter	Focal spindle cell proliferation consistent with PMT
21 *	+	+	+	Left popliteal fossa	Epitheloid/spindle cell neoplasm consistent with PMT
22	+	−	+	Left frontal lobe intracranial mass	NA (not resected)
23	+	+	ND	Right proximal tibia	PMT, mixed connective tissue type
26	+4	+	+	Right periosteal nodule proximal tibia	Spindle cell neoplasm consistent with PMT
28	+	ND	ND	Left distal humerus periosteal-associated soft tissue mass	Spindle cell tumor with features of PMT
29	+	+	+	Left lesser trochanter	Spindle cell lesion consistent with PMT
30	+	+	+	Left foot, plantar surface	Spindle cells and cartilaginous area with numerous osteoclast-like giant cells consistent with PMT
31	+	−	+	Right arm, volar aspect, just below elbow	51-PMT; 2- PMT, mixed connective tissue variant; 3- lipoma; 4- hemangioma with lipomatous component and small portions of PMT in the periphery
No. Positive	18	14	11
No. Negative	1	2	2
No. Not Done	1	4	7
Not Localized:
Subject Number	Octreotide	FDG PET/CT	Venous Sampling	Tumor Location	Histopathological Diagnosis
4	−	+	ND	NA	NA
7	+6	+	−	NA	NA
8	−	+	ND	NA	NA
9	+	+	−	NA	NA
12	−	−	ND	NA	NA
17	−	−	ND	NA	NA
18	+	+	+7	NA	NA
20	−	−	+8	NA	NA
24	+	+	−	NA	NA
25	−	−	ND	NA	NA
27	−	+	−	NA	NA
No. Positive	4	7	2
No. Negative	7	4	4
No. Not Done	0	0	5

No. = number, + = positive study, - = negative study, ND = not done, NA = not applicable, * = subjects were positive control subjects in venous sampling study (Andreopoulou et al.), PMT = phosphaturic mesenchymal tumor

¹Negative venous sampling performed as part of evaluation of recurrent disease. Not done at initial evaluation

²Needle aspiration of suspected lesion, venous sampling negative

³Tumor resected prior to performing octreo-SPECT.

⁴Lesion seen on octreo-SPECT only after identified on FDG-PET/CT

⁵Pleimorphic tumor with multiple distinct areas in a PTEN mutation negative patient who met clinical criteria for Cowden syndrome

⁶Surgery of lesion seen on octreotide did not result in resolution of disease. Lesion remained on post-operative anatomic imaging. Five year follow-up octreo-SPECT was negative

⁷Two suspicious sites on imaging. Venous sampling positive for one of two sites. Subject ultimately had surgery of both sites w/o resolution of disease

⁸Suspicious lesion identified on PET and venous sampling suggested that identified lesion was the source. Surgery was performed at an outside institution; pathology was consistent with enchondroma. Disease persisted post-operatively.