Table 2.
Genotype distributions, minor allele frequencies and unadjusted p-values for comparing genotype distribution according to diabetes status, additive allelic effects between diabetes groups
| Non-diabetic | Diabetic | p-value | Overall | |
|---|---|---|---|---|
| N |
575 |
212 |
|
787 |
|
IRS1
|
|
|
|
|
| G/G, n (%) |
526 (91.5) |
199 (93.9) |
0.485 |
725 (92.1) |
| G/A, n (%) |
48 (8.3) |
13 (6.1) |
|
61 (7.7) |
| A/A, n (%) |
1 (0.2) |
0 (0) |
|
1 (0.1)) |
| A, n (%) |
50 (4.4) |
13 (3.1) |
0.131 |
63 (4.0) |
| HWE (p-value) |
>0.999 |
>0.999 |
|
>0.999 |
|
PPARG
|
|
|
|
|
| C/C, n (%) |
521 (90.6) |
183 (86.3) |
0.161 |
704 (89.4) |
| C/G, n (%) |
53 (9.2) |
29 (13.7) |
|
82 (10.4) |
| G/G, n (%) |
1 (0.2) |
0 (0) |
|
1 (0.1) |
| G, n (%) |
55 (4.9) |
29 (6.8) |
0.012 |
84 (5.3) |
| HWE (p-value) | >0.999 | 0.605 | 0.719 |
HWE, Hardy-Weinberg Equilibrium (HWE p-values are from exact tests). IRS1, Insulin Substrate Receptor 1; PPARG, Peroxisome Proliferator-Activated Receptor Gamma.